… Using models adjusted only for age and gender, we found evidence for association with
serum UA concentration for four of the five novel reported loci: PDZK1 (rs12129861, P = 1.07 × …

… the largest variation in uric acid concentration, ranging from 2·8% to 5·3% in white … new
loci, ABCG2 and SLC17A3, that show association with uric acid concentration and risk of gout…

… uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. The
regulation of serum uric acid levels … loci are associated with uric acid concentrations, five of …

… populations, and uric acid stones account for 5%–10… uric acid stones, and performed a
genomewide search in a deep-rooted pedigree comprising many members who formed uric acid …

… with sequence variants at several loci. Initially, a variant at … uric acid levels 4,5,6,7 . Two
meta-analyses yielded variants at nine loci that associate significantly with serum uric acid levels …

… Therefore, identifying new loci may not only help elucidate the pathophysiology of these
diseases… at 36 genetic loci with a P value of <5 × 10 –8 for SUA (Fig. 1). Among these 36 genetic …

… been associated with serum urate levels with the collective 28 … the new loci contain obvious
uric acid transporters, with loci … of GCKR with gout in Polynesian (OR=1.38, p=6.6×10 −5 ) for …

… loci suggestive of association with uric acid levels (SEMA5A, TMEM18, SLC28A2, and ODZ2),
although the P-values (P < 5… -related genetic variants and highlight suggestive new loci for …

… have identified several genetic variants as susceptibility loci for serum uric acid (UA) levels.
We also identified a common nonsense … The highest odds ratio in subjects with 5 or 6 risk …

… Therefore, five novel loci associated with serum UA levels emerged from this meta-analysis
[7… analyzed these new and known loci for their association with the clinical phenotype gout in …