Natural production of fluorinated compounds and biotechnological prospects of the fluorinase enzyme

MF Carvalho, RS Oliveira - Critical reviews in biotechnology, 2017 - Taylor & Francis
… and rocks, though their concentrations and production mechanisms are not well known. This
… about fluorinated compounds with natural origin. The paucity of these compounds and the …

Natural and engineered biosynthesis of fluorinated natural products

MC Walker, MCY Chang - Chemical Society Reviews, 2014 - pubs.rsc.org
… bioactive compounds but our ability to produce site-selectively fluorinated natural products
… and current methods for fluorination. Living systems provide an alternative route to chemical …

[HTML][HTML] Enzymatic synthesis of fluorinated compounds

X Cheng, L Ma - Applied Microbiology and Biotechnology, 2021 - Springer
… of which are fluorinated natural products of various structures. However, there are still very
fluorinated natural products found in nature. The main known fluorinated natural products in …

Fluorinated natural products: Occurrence and biosynthesis

DB Harper, D O'Hagan, CD Murphy - Natural production of …, 2003 - Springer
… the participation of fluorine in biochemical processes is the … precludes incorporation of
fluorine into natural products by the … which organohalogen compounds are formed in nature [5]. …

The rare fluorinated natural products and biotechnological prospects for fluorine enzymology

KKJ Chan, D O'Hagan - Methods in enzymology, 2012 - Elsevier
… The known fluorinated natural products. Fluoroacetate is found in many plants and in one
bacterium (Streptomyces cattleya). Fluoroacetate is toxic because it is converted to (2R,3R)-2-…

Fluorine-containing natural products

D O'Hagan, DB Harper - Journal of Fluorine Chemistry, 1999 - Elsevier
… In this article we review the fluorinated natural products and … fluorinated natural products
have been isolated excluding the fatty acid homologues [3]. The first organo-fluorine compound

The fluorinated natural products

D áO'Hagan - Natural product reports, 1994 - pubs.rsc.org
… effective method for studying the metabolism of fluorinated compounds, and with the dramatic
… , the technique is an attractive tool with which to screen for novel fluorinated metabolites. …

Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya

CD Murphy, C Schaffrath, D O'Hagan - Chemosphere, 2003 - Elsevier
… for introducing fluorine into organic compoundsproduced fluorinated compounds and focus
on the work that has been done to elucidate the biochemistry of fluorometabolite production

The natural production of chlorinated compounds

GW Gribble - Environmental science & technology, 1994 - ACS Publications
… Not only are naturally occurring organohalogen compounds … several fluorine-containing
natural products exist (4), the presentreview focuses principally on organochlorine compounds. …

Synthetic biology approaches to fluorinated polyketides

BW Thuronyi, MCY Chang - Accounts of chemical research, 2015 - ACS Publications
fluorine into complex natural products by engineering biosynthetic machinery to incorporate
fluorinated … select for fluorinated compounds, we have studied one of the only characterized …