… of some behavioral responses, such … transgenic rescue of abnormal social responses in
Fmr1KO mice. Relative to their wild-type (WT) littermates, Fmr1KO mice made more active social …

… that the Fmr1 KO mouse might provide a valid model for autistic features. In a first step, we
evaluated the social behavior of Fmr1 KO mice, because deficits in social behavior are among …

… findings on social behavior in the Fmr1 knockout mouse … whether Fmr1 KO mice differ from
WT mice in social behavior … lack of social novelty preference and increased social anxiety…

… social behaviors are prominent features of FXS in humans. To better understand the role of
FMR1 in these behaviors, … the FMR1 YAC transgenic mice, indicating a role for the Fmr1 gene …

… interpretations of social behavior scores. Overall, results show that loss of Fmr1 or Slc6a4
gene … mice, the Igf-1 transgenic mice did not show deficits in social approach or in any other …

… neonatal Fmr1 KO mice and transgene expression and behavioral assessments … behavior
and the deficit in social dominance behavior seen in phosphate-buffered saline-injected Fmr1 …

… In summary, transgenic overexpression of human FMRP corrected enhanced prepulse
inhibition response in mice lacking murine fmrp. These results further support the contention that …

… Here we describe two of the first transgenic rat models for ASD, developed using zinc-finger …
direct social behaviors, only exhibiting deficits on play measures. The rat as a behavioral …

… endogenous human FMR1 promotor in the transgenic mice versus … in the transgenic mice
versus FMRP transgene expression … ) and behavioral rescue were apparent in Fmr1 KO mice …

… behaviors resulting from the loss of Fmr1 gene expression, we generated F1 hybrid lines from
female Fmr1 … Importantly, this behavior was corrected by transgenic expression of FMRP in …