… 1 pathway for the development of prostate cancer. The finding of mutations in genes involved
in the innate immune response to infection in the germline of prostate cancer … focused on …

… in regulation of major molecular pathways in prostate cancer is discussed. Finally, we
describe currently applied therapeutics in targeting lncRNAs for prostate cancer therapy. …

… Few studies have used pure populations of prostate cancer cells, and efforts have focused
primarily on biomarker discovery and less on pathway analysis thus limiting their utility. Here, …

… Additional studies investigating genetic variation in DNA repair, carcinogen metabolism,
and inflammation pathways as risk factors for prostate cancer are underway. While on an …

… Nevertheless, current research has primarily focused on assessing canonical Wnt/β-catenin
pathway components. Future work exploring key components of non-canonical Wnt/PCP …

… in prostate cancer is deregulated and plays an important role in cancer progression. In this
… between commonly deregulated pathways in prostate cancer and cholesterol metabolism. …

… The concept of the ‘prostate cancer patient journey’ provided an overarching framework for
the analysis, reflecting both the focus of the research on the changing nature of uncertainty …

… progression in castration-resistant prostate cancer; thus, therapeutic potential … focuses on
agents in clinical development targeting apoptosis through the intrinsic and extrinsic pathways. …

… focusing on the intrinsic apoptosis pathway, and consider how BH3 mimetics may be used
to help treat prostate cancer… and apoptosis, specifically focusing on the intrinsic pathway. It …

… epithelial cells, the role of BCL-2 family proteins in this process and the signaling pathways
that target these proteins. We choose to focus on “druggable” signaling pathways for which …