Cancer immunotherapy: a focus on the regulation of immune checkpoints

T Shi, Y Ma, L Yu, J Jiang, S Shen, Y Hou… - International journal of …, 2018 - mdpi.com
focused on different aspects of the regulation of immune checkpoints in the TME (tumor
microenvironment), including regulation … intestinal flora and mutual regulation by various immune …

Immune checkpoint inhibitors in cancer therapy: a focus on T‐regulatory cells

V Sasidharan Nair, E Elkord - Immunology and cell biology, 2018 - Wiley Online Library
… and clinical benefits in patients with cancer at late stages. Most studies … how ICIs may target
Tregs for cancer immunotherapy. … In this review, we focus on the impact of inhibitors against …

Biochemical aspects of PD-L1 regulation in cancer immunotherapy

J Zhang, F Dang, J Ren, W Wei - Trends in biochemical sciences, 2018 - cell.com
… , we primarily focus on summarizing PD-L1 regulation and its potential roles in regulating
antitumor … to optimize anti-PD-1/PD-L1 therapies, benefiting a wider cancer patient population. …

Differentiation and Regulation of TH Cells: A Balancing Act for Cancer Immunotherapy

A Basu, G Ramamoorthi, G Albert, C Gallen… - Frontiers in …, 2021 - frontiersin.org
… effects of T H cells, with an emphasis on regulation of different T H cell subtypes by various
… influence overall success of cancer immunotherapy. We focus on the regulatory network that …

Regulatory cells and the effect of cancer immunotherapy

M Iglesias-Escudero, N Arias-González… - Molecular cancer, 2023 - Springer
… to reduce regulatory cells in cancerregulatory cells in cancer patients. Some approaches
aim to reduce the frequency, function and extent of blocking mobilization, while others focus on …

[HTML][HTML] Why Treg should be the focus of cancer immunotherapy: The latest thought

Z Liu, J Zhou, S Wu, Z Chen, S Wu, L Chen… - Biomedicine & …, 2023 - Elsevier
… , and to be able to use regulatory T cells for tumor immunotherapy more quickly. This review
focuses on the research progress of various mechanisms of regulatory T cells in the tumor …

Innate immune signaling and regulation in cancer immunotherapy

L Corrales, V Matson, B Flood, S Spranger… - Cell research, 2017 - nature.com
… also can be predictive for response to contemporary cancer immunotherapies. The generation
of a … that can respond to immunotherapies, such as with checkpoint blockade antibodies. …

Regulatory T cells in cancer immunotherapy

H Nishikawa, S Sakaguchi - Current opinion in immunology, 2014 - Elsevier
… This review focuses on our current understanding of the roles of FOXP3 + Treg cells in
tumor … or functional manipulation of Treg cells as a key strategy in cancer immunotherapy. …

MicroRNAs in immune regulation—opportunities for cancer immunotherapy

H Okada, G Kohanbash, MT Lotze - … journal of biochemistry & cell biology, 2010 - Elsevier
… in focus MicroRNAs in immune regulation—Opportunities for cancer immunotherapy☆ …
overcome some of our current challenges in cancer immunotherapy. Continued basic studies and …

Anti-cancer immunotherapy: breakthroughs and future strategies

MH Andersen - Seminars in immunopathology, 2019 - Springer
… Thus, both cancer cells and other regulatory immune cells release inhibitory cytokines and …
PD1/PDL1 immunotherapy. Until recently, the main focus of cancer immunotherapy has been …