Promising targeted treatments and immunotherapy strategies in oncology and advancements
in our understanding of molecular pathways that underpin cancer development have …

… Folate receptor α (FRα) … folate metabolism, such as methotrexate and pemetrexed. Binding
to FRα is one of several methods by which folate is taken up by cells; however, this receptor is …

OBJECTIVES.: Folate receptor α (FRα) is a folate-binding protein overexpressed on ovarian
and several other epithelial malignancies that can be used as a target for imaging and …

… Folate receptor alpha (FRα), a glycosyl phosphatidylinositol linked protein with a great
affinity for folic acid and some reduced folates such as 5-methyltetrahydrofolate and …

… The association between folate receptor alpha expression … Folate receptor alpha expression
was shown to have a high … were positive for folate receptor alpha expression, our results …

… In this work we examined the hypothesis that folate receptor alpha (FRα) acts as a …
Until this time FRα has only been considered as a folate transporter, these studies describe …

… antifolate and folate receptor agents being developed for ovarian cancer including thymidylate
synthase inhibitors, antifolate receptor antibodies, and folate-chemotherapy conjugates. …

… The folate receptor alpha (FRα) is one logical choice for a biomarker because of its prevalent
overexpression in ovarian cancer and its exclusive expression in only a few normal tissues. …

… identities but mediate unidirectional transport of folates into cells. Four isoforms of this receptor
family have been identified and are designated as folate receptor alpha (FRA), beta (FRB)…

… Folate receptor alpha (FRA) is overexpressed in the majority of NSCLC, particularly in
lung adenocarcinomas. FRA is largely absent from normal tissue, making it an attractive …