… One potential target is the alpha isoform of the folate receptor (FR), which … cancer and
nonsmall-cell lung cancer (NSCLC). In this review, we discuss the concept of personalized cancer …

… receptor is confined to the apical surface of the epithelium that is out of direct contact with
folate and any folate receptor-… as a salvage receptor to retrieve and prevent loss of folate in the …

… All three proteins have a key role in folate uptake, although the … folate receptor-α (FRα) has
emerged following the completion of late-phase trials involving patients with ovarian cancer …

… Over the last 25+ years, the folate receptor (FR) has … and retention of natural folates, certain
antifolates, and folate‐drug … responsible for whole body retention of folates (eg, kidney and …

… a Folate can be transported into the cell by three different proteins: the folate receptor (FR)
(panel A), the reduced folate carrier (RFC) (panel B), and the proton-coupled folate …

… of folate receptors and transporters; Folate receptors for targeting … -folate drugs for treating
inflammatory diseases and cancer; … ; and Chimeric Antigen Receptor cell therapies of cancer. …

… Methods are being proposed and tested that could target treatments more directly to cancer
… that employ folate nanoconjugates to target the folate receptor. Folate receptors are highly …

… the expression of the folate receptor in breast cancers in greater detail. To … folate
receptor-positive cells, we studied its expression in a set of good and poor-outcome breast cancers…

… this protein in ovarian cancer treatment. This … of folate receptors as prognostic and predictive
biomarkers as well as their role in the management and targeted therapy of ovarian cancer. …

… tumor epithelial ovarian cancer expression increases … folate uptake from serum8 or by
generating regulatory signals.4, 9 This review summarizes folate's role in cancer, compares folate …