DNA methylation: eukaryotic defense against the transcription of foreign genes?
W Doerfler - Microbial pathogenesis, 1992 - Elsevier
… occurrence of de novo methylation of foreign DNA in mammalian cells. We have now
demonstrated that the de novo methylation of foreign (adenovirus) DNA is initiated at sequences …
demonstrated that the de novo methylation of foreign (adenovirus) DNA is initiated at sequences …
Foreign DNA integration: genome-wide perturbations of methylation and transcription in the recipient genomes
K Muller, H Heller, W Doerfler - Journal of Biological Chemistry, 2001 - ASBMB
… BecauseIL-10 and Igf2r are located on different mouse chromosomes, we reason that at least
one of the genes with altered DNA methylation is located in trans to the transgene insertion …
one of the genes with altered DNA methylation is located in trans to the transgene insertion …
On the biological significance of DNA methylation
W Doerfler - Biochemistry (Moscow), 2005 - Springer
… We propose that hyper or nearly completely 5′ CG 3′ methylated foreign DNA sequences
would be more stably integrated than less completely methylated foreign genomes. …
would be more stably integrated than less completely methylated foreign genomes. …
Epigenetic consequences of foreign DNA insertions: de novo methylation and global alterations of methylation patterns in recipient genomes
W Doerfler - Reviews in medical virology, 2011 - Wiley Online Library
… of DNA methylation patterns in the recipient genome at and remote from the site of foreign
DNA … We concluded that the trans-effect of foreign DNA insertion on cellular DNA methylation …
DNA … We concluded that the trans-effect of foreign DNA insertion on cellular DNA methylation …
Methylation of foreign DNA sequences in eukaryotic cells.
Y Pollack, R Stein, A Razin… - Proceedings of the …, 1980 - National Acad Sciences
… of DNA methylation … foreign DNA was unmethylated, we questioned whether this was unique
to the HSV and plasmid DNAs used in the study. These vectors are not naturally methylated …
to the HSV and plasmid DNAs used in the study. These vectors are not naturally methylated …
Insertion of foreign DNA into an established mammalian genome can alter the methylation of cellular DNA sequences
R Remus, C Kämmer, H Heller, B Schmitz… - Journal of …, 1999 - Am Soc Microbiol
… the changes in DNA methylation of cellular DNA segments in Ad12-transformed cells is very
likely, we have now investigated whether the integration of foreign DNA into the established …
likely, we have now investigated whether the integration of foreign DNA into the established …
The importance of DNA methylation for stability of foreign DNA in barley
SW Rogers, JC Rogers - Plant molecular biology, 1992 - Springer
… ' reporter genes driven by aleurone tissue-specific promoters to test the effect of methylation
of foreign DNA on its stability after introduction into barley plants. The foreign DNA was …
of foreign DNA on its stability after introduction into barley plants. The foreign DNA was …
Foreign DNA integration and DNA methylation patterns
W Doerfler - Functional Analysis of the Human Genome, 2020 - taylorfrancis.com
… methylation … DNA methylation in tumour cells, particularly in adenovirus type 12 (AdI2)-induced
hamster tumour cells. It is not known whether these changes in cellular DNA methylation …
hamster tumour cells. It is not known whether these changes in cellular DNA methylation …
DNA methylation
R Singal, GD Ginder - Blood, The Journal of the American …, 1999 - ashpublications.org
… global mechanisms of gene regulation, DNA methylation and histone … foreign DNA and
transgenic organisms, the newly integrated foreign DNA frequently becomes de novo methylated…
transgenic organisms, the newly integrated foreign DNA frequently becomes de novo methylated…
DNA methylation: a defense mechanism against the expression of foreign DNA?
W Doerfler - DNA—technology and its forensic application, 1991 - Springer
… Since cell lines propagated in culture and adenovirus genomes as foreign DNA in … analyzed
patterns of DNA methylation in a number of endogenous human gene or DNA segments in …
patterns of DNA methylation in a number of endogenous human gene or DNA segments in …
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