Oral formulation strategies to improve solubility of poorly water-soluble drugs

A Singh, ZA Worku… - Expert opinion on drug …, 2011 - Taylor & Francis
solubility of the active pharmaceutical ingredient. Therefore, the importance of formulation
strategies to improve the solubility of … of currently relevant formulation strategies and proposes …

Solubility and dissolution enhancement strategies: current understanding and recent trends

S Jain, N Patel, S Lin - Drug development and industrial pharmacy, 2015 - Taylor & Francis
Poor aqueous solubility of these lipophilic compounds can drastically affect … -formulation
and formulation strategies have been applied in the past that can improve the aqueous solubility

Novel strategies for the formulation and processing of poorly water-soluble drugs

K Göke, T Lorenz, A Repanas, F Schneider… - European Journal of …, 2018 - Elsevier
… Also incorporation into nanospun fibers may help to overcome issues with the poor solubility
of APIs. Some of the strategies to formulate poorly water-soluble drug substances offer …

Strategies for formulating and delivering poorly water-soluble drugs

M Rodriguez-Aller, D Guillarme, JL Veuthey… - Journal of Drug Delivery …, 2015 - Elsevier
… Water solubility is a key parameter in drug formulation since it highly influences drug … and
discusses the pharmaceutical strategies available to overcome poor water solubility in light of …

When poor solubility becomes an issue: from early stage to proof of concept

S Stegemann, F Leveiller, D Franchi, H De Jong… - European journal of …, 2007 - Elsevier
… the drug discovery and formulation development in the late … poor solubility on analytical
evaluation, prediction of oral absorption, substance selection, material and formulation strategies

Overview of nanoparticulate strategies for solubility enhancement of poorly soluble drugs

KU Khan, MU Minhas, SF Badshah, M Suhail, A Ahmad… - Life Sciences, 2022 - Elsevier
Poor solubility has been recognized as crucial factor and notorious by affecting … It is well
known that poor solubility is huge issue with formulation development of new chemical entities (…

[HTML][HTML] Insoluble drug delivery strategies: review of recent advances and business prospects

S Kalepu, V Nekkanti - Acta Pharmaceutica Sinica B, 2015 - Elsevier
… Issues associated with poor solubility can lead to low bioavailability resulting in suboptimal
… associated with poor solubility and low bioavailabilities have been formulated into successful …

Drug delivery strategies for poorly water-soluble drugs

A Fahr, X Liu - Expert opinion on drug delivery, 2007 - Taylor & Francis
… With this formulation, the water solubility of nine poorly water-soluble drugs, such as
ibuprofen, ketoprofen, tamoxifen, testosterone, tolbutamide and other new compounds, was …

Drug delivery strategies for poorly water-soluble drugs: the industrial perspective

P van Hoogevest, X Liu, A Fahr - Expert opinion on drug delivery, 2011 - Taylor & Francis
poor solubilityformulation strategy may be best for a drug, a correlation between the physical
form of the drug substance in the formulation and possible parenteral and oral formulation

Nanonization techniques to overcome poor water-solubility with drugs

FLO Da Silva, MBDF Marques, KC Kato… - Expert opinion on drug …, 2020 - Taylor & Francis
… An unfavorable pharmacokinetic profile can be indicative of the need for strategic
pharmaceutical formulations and processing technologies. Thus, the low absorption and the …