… In Table 3 we summarize the medical information of 16 patients of the DR8 founder
family who carried the IVS0 + 5G>C null mutation. Both AD patients DR25.14 and DR142.1 …

… Mutation carriers have a conserved haplotype of 3.7 cM … in 18 families, indicating that this
is a founder mutation within the … of these families has made it possible to identify the founder …

… The Hispanic 185delAG carrier families share the same … of BRCA mutations among high-risk
Hispanic families in major … of BRCA mutations among Hispanic families attending a high-…

… base pairs in some carriers, which tells us that the founder mutation is extremely ancient— …
fact that all humans are indeed members of a single family, bound together by the shared …

… About 420 families with germline TP53 mutations have been … In this study, we have further
assessed the probability of a founder effect … R337H mutation. These results demonstrate a …

… 4 cases of breast cancer in the family 52% of high-risk families can be linked to BRCA1 (…
mutation carriers (35%) in our sample set seems to be high considering that most families (10/15…

… mutation carriers were conducted in high-risk families, and have suggested an elevated risk
of several types of cancers in carrier families… (CC) in BRCA1 carriers; however, these studies …

… This phenomenon, called “founder effect” was proved in carrier families by haplotype …
founder alleles (267 bp and 292 bp) are represented with highest frequency in our mutation carrier …

… mutation and of the likelihood of a mutation carrier developing cancer should be possible. For
a given founder mutation a large number of carriers … among families with founder mutations…

… The prevalence of mutations in families with defined ODA defect was 13%; no … His unaffected
sibling was a carrier of the novel exon 19 mutation; this mutation was inherited from the …