… in drug resistant cancers. Given its pivotal roles in drug sensitivity as well as resistance,
targeting the FOXO-FOXM1 axis could be a viable strategy for treatment of cancer and for …

… that compared with other FOXO proteins, FOXO3 has a … , FOXM1 and other upstream or
downstream targets in the signalling pathways, could be a feasible strategy for cancer treatment …

… also compete for binding to the same gene targets, which have a role in chemotherapeutic
… of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug …

… effect induced by CAR and accelerated the FOXM1 expression. Our data confirmed that CAR
exerted an anti-tumor function in PC dependently by modulating the FOXO3a-FOXM1 axis. …

… FOXM1 suppression by STL427944 validates a unique pathway to overcome tumor
chemoresistance and improve the efficacy of treatment … ], we evaluated FOXO1 and FOXO3A …

… of FOXM1 in various aspects of cancer, in particular its role and regulation within the context
of cancer initiation, progression, and cancer … by FOXO3a and FOXM1 in breast cancer cells …

… that chemotherapeutic drugs integrate their signals with FOXO3a … While the FOXOs are bona
fide tumor suppressors, another … protein M1 (FOXM1), behaves like a classic oncogene. The …

… To determine whether FOXO3a and FOXM1 also modulates VEGF transcription, we first …
, FOXM1 and FOXO3a upon lapatinib treatment of responsive and resistant breast cancer cell …

… reduces FOXM1 by counteracting the AKT/FOXO3a/FOXM1 signaling axis. Our findings
shed light on the application of AMPK activators in the treatment of human cervical cancer. …

… -regulate FOXM1 expression. Doxorubicin causes nuclear translocation of FOXO3a by inducing
… of PI3K-AKT -FOXO3a-FOXM1 pathways for the treatment of cancer as shown in Fig. ​3. …