An etiological Foxp2 mutation impairs neuronal gain in layer VI cortico-thalamic cells through increased GABAB/GIRK signaling
M Druart, M Groszer… - Journal of Neuroscience, 2020 - Soc Neuroscience
… , the role of Foxp2 in neocortical neurons is poorly understood. Using mice with a Foxp2
mutation … , we studied functional modifications in auditory cortex neurons ex vivo. We found that …
mutation … , we studied functional modifications in auditory cortex neurons ex vivo. We found that …
An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning
… running, more neurons were found to increase firing rate in … However, we found that
Foxp2-R552H/+ neurons with high … significant proportion of Foxp2-R552H/+ neurons were unable …
Foxp2-R552H/+ neurons with high … significant proportion of Foxp2-R552H/+ neurons were unable …
Foxp2 loss of function increases striatal direct pathway inhibition via increased GABA release
… the stop-gain Foxp2 mutation (S321X). Foxp2 protein expression is absent in Foxp2 S321X/…
and maintenance of neuronal circuitry, we examined the role of Foxp2 in striatal inhibition. …
and maintenance of neuronal circuitry, we examined the role of Foxp2 in striatal inhibition. …
What can mice tell us about Foxp2 function?
… [55 • ], a claim that has gained widespread attention. However, there are grounds for caution.
… of its neural functions. Neurite outgrowth and synaptic plasticity are two processes in which …
… of its neural functions. Neurite outgrowth and synaptic plasticity are two processes in which …
Foxp2 regulates neuronal differentiation and neuronal subtype specification
YC Chiu, MY Li, YH Liu, JY Ding, JY Yu… - Developmental …, 2014 - Wiley Online Library
… Foxp2 increased neuronal differentiation without affecting cell proliferation and cell survival
in primary neural … whether Foxp2-regulated neuronal differentiation, we performed gain-of-…
in primary neural … whether Foxp2-regulated neuronal differentiation, we performed gain-of-…
Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons
HY Kuo, SY Chen, RC Huang, H Takahashi, YH Lee… - Brain, 2023 - academic.oup.com
… in the growth cone of developing neurons. Intracellular endosome trafficking is known to …
is a target gene of Foxp2 in neurons of the striatum and that Foxp2-Dctn1 signalling can …
is a target gene of Foxp2 in neurons of the striatum and that Foxp2-Dctn1 signalling can …
FOXP2 and the role of cortico-basal ganglia circuits in speech and language evolution
W Enard - Current opinion in neurobiology, 2011 - Elsevier
… expression and etiology (see above), we found that humanized Foxp2 leads to an increase
in total dendrite length in vitro and in vivo. Recording from these neurons in acute slices, we …
in total dendrite length in vitro and in vivo. Recording from these neurons in acute slices, we …
FOXP Genes, Neural Development, Speech and Language Disorders
H Takahashi, K Takahashi, FC Liu - … factors: vital elements in biology and …, 2010 - Springer
… mutation in FOXP2 in a family with a speech and language disorder opened a new window
to understanding the geneticcascades and neural … and postnatal weight gain, but were able …
to understanding the geneticcascades and neural … and postnatal weight gain, but were able …
Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain
… Foxp2-positive neurons derived from the developing basal ganglia show altered neurite
outgrowth when the gene is mutated… (Drd2) MSNs continue to increase their dendritic area well …
outgrowth when the gene is mutated… (Drd2) MSNs continue to increase their dendritic area well …
FoxP2 regulates neurogenesis during embryonic cortical development
D Tsui, JP Vessey, H Tomita, DR Kaplan… - Journal of …, 2013 - Soc Neuroscience
… To ask about a potential function for FoxP2 in these neural precursors, we generated two …
This analysis demonstrated that FoxP2 knockdown caused an increase in the proportion of …
This analysis demonstrated that FoxP2 knockdown caused an increase in the proportion of …
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