Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons
HY Kuo, SY Chen, RC Huang, H Takahashi, YH Lee… - Brain, 2023 - academic.oup.com
… We demonstrate that Dctn1 is a target gene of Foxp2 in neurons of the striatum and that
Foxp2-Dctn1 signalling can regulate the development of striatal circuits affecting vocalization …
Foxp2-Dctn1 signalling can regulate the development of striatal circuits affecting vocalization …
An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning
… the Foxp2 mutation on the dynamic changes in striatal plasticity that are observed during
motor-skill learning. We determined whether the firing rate of striatal neurons … striatum neurons …
motor-skill learning. We determined whether the firing rate of striatal neurons … striatum neurons …
Expression of Foxp2, a gene involved in speech and language, in the developing and adult striatum
K Takahashi, FC Liu, K Hirokawa… - Journal of …, 2003 - Wiley Online Library
… in patients with Foxp2 mutation may be related to dysfunction of the striosomal system in
the … from its rodent counterpart in striatal neurons, which permits the striatal system to have …
the … from its rodent counterpart in striatal neurons, which permits the striatal system to have …
Foxp2 loss of function increases striatal direct pathway inhibition via increased GABA release
… reduced Foxp2 expression, via a loss-of-function mutation, on striatal medium spiny neurons
(… and maintenance of neuronal circuitry, we examined the role of Foxp2 in striatal inhibition. …
(… and maintenance of neuronal circuitry, we examined the role of Foxp2 in striatal inhibition. …
[PDF][PDF] The role of FoxP2 in striatal circuitry
J Rhijn - 2019 - repository.ubn.ru.nl
… disruption of Foxp2 affects striatal circuitry is mutationspecific… of FOXP2 in these human
dopaminergic neurons leads to … mouse striatal neurons with heterozygous loss of FOXP2 function…
dopaminergic neurons leads to … mouse striatal neurons with heterozygous loss of FOXP2 function…
[PDF][PDF] The role of FoxP2 in striatal circuitry
JR Van Rhijn - 2019 - pure.mpg.de
… disruption of Foxp2 affects striatal circuitry is mutationspecific… of FOXP2 in these human
dopaminergic neurons leads to … mouse striatal neurons with heterozygous loss of FOXP2 function…
dopaminergic neurons leads to … mouse striatal neurons with heterozygous loss of FOXP2 function…
Differential and overlapping pattern of Foxp1 and Foxp2 expression in the striatum of adult mouse brain
WL Fong, HY Kuo, HL Wu, SY Chen, FC Liu - Neuroscience, 2018 - Elsevier
… Genetic mutations of FOXP1 and FOXP2 are associated with neurodevelopmental … and
Foxp2 with respect to specific cell types of projection neurons and interneurons in the striatum of …
Foxp2 with respect to specific cell types of projection neurons and interneurons in the striatum of …
FOXP Genes, Neural Development, Speech and Language Disorders
H Takahashi, K Takahashi, FC Liu - … factors: vital elements in biology and …, 2010 - Springer
… aspects in which Foxp2/FoxP2 striatal expression differs in … striosomal FoxP2 expression
pattern in the monkey striatum is … mutants, some neurons had nuclearaggregates of Foxp2 …
pattern in the monkey striatum is … mutants, some neurons had nuclearaggregates of Foxp2 …
Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c
YC Chen, HY Kuo, U Bornschein, H Takahashi… - Nature …, 2016 - nature.com
… We demonstrate that in the mouse striatum, the gene Foxp2 … and striatal spinogenesis
defects of Foxp2-deletion mutants. … to synapse progressively onto striatal neurons, thus building …
defects of Foxp2-deletion mutants. … to synapse progressively onto striatal neurons, thus building …
Human IPSC derived dopaminergic neurons show reduced activity following heterozygous FOXP2 knockout
JR Van Rhijn, Y Shi, NN Kasri, D Schubert - frontiersin.org
… Neuronal dysfunction caused by impaired FOXP2 function could lead to a strong cellular …
FOXP2 mutations indeed show impaired striatal grey matter volume and reduced striatal activity…
FOXP2 mutations indeed show impaired striatal grey matter volume and reduced striatal activity…
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