… A previous report of 24 families (5) had suggested that a high frequency of second malignant
neoplasms occurred in the LiFraumeni syndrome, and confirmation of that association was …

Approximately 10% of cases of childhood cancer arise in the context of a cancer predisposition
syndrome (CPS)[1]. Among the rare CPS, Li–Fraumeni syndrome (LFS, MIM# 151623) is …

… Li Fraumeni syndrome (LFS) or Chompret criteria. A simplified prevalence table provides
a concise summary of individual and family characteristics associated with p53 mutations. …

… , they retrospectively evaluated 280 medical charts and 418 … gene is located on the short
arm of human chromosome 17 band 13.1 [14]. Extensive characterization of the TP53 gene …

… Clinical Findings The classic clinical characterization of LFS by Li and Fraumeni includes
an initial patient with a sarcoma, a first-degree relative with cancer before the age of 45 years, …

… characteristics between Caucasian and Korean patients. This is the first report on the mutation
spectrum and clinical characteristics … the mutation features and clinical characteristics, …

… The completion of the Human Genome Project provided a virtual dictionary of gene and … of
diseases as well as particular traits and characteristics. One disease state that was likely to be …

… Individuals with or suspected of having LFS based on clinical or molecular criteria should
seek a cancer genetics consultation to review the diagnosis and medical management …

… be responsible for clinical heterogeneity. In this review, recent advances in the understanding
of genetic and epigenetic aspects influencing Li–Fraumeni phenotype are discussed. …

… Li–Fraumeni syndrome (LFS) is a hereditary tumor that exhibits autosomal dominant
inheritance. LFS develops in individuals with a pathogenic germline variant of the cancer-…