What is the role for population pharmacokinetics in hemophilia?

A Iorio, A McEneny-King, A Keepanasseril… - International journal …, 2017 - Taylor & Francis
… preventing joint damage in hemophilia patients, as episodic … (ie, combination of dose and
frequency) and subsequently using … field of hemophilia, basic knowledge on PK estimates and …

Joint bleeding tendencies in adult patients with hemophilia: it's not all pharmacokinetics

JY Zhou, RFW Barnes, G Foster… - Clinical and Applied …, 2019 - journals.sagepub.com
frequencyestimates of half-life or Vd were taken from the respective pharmaceutical
companies’ drug inserts. We used patients’ infusion logs to build a simulation model to estimate

[HTML][HTML] Economic burden of illness among persons with hemophilia B from HUGS Vb: examining the association of severity and treatment regimens with costs and …

CX Chen, JR Baker, MB Nichol - Value in Health, 2017 - Elsevier
estimates for HA [14]. In addition, this study found generally low health care resource utilization
among patients … who have a higher bleeding frequency tend to use prophylactic treatment…

Prophylaxis usage, bleeding rates, and joint outcomes of hemophilia, 1999 to 2010: a surveillance project

MJ Manco-Johnson, JM Soucie… - Blood, The Journal of the …, 2017 - ashpublications.org
… The analysis was performed using a mixed linear regression model to estimate the random
… of the participating patients with severe hemophilia A and their hemophilia treatment center …

Treatment patterns and bleeding outcomes in persons with severe hemophilia A and B in a real-world setting

C Ay, L Perschy, J Rejtö, A Kaider, I Pabinger - Annals of Hematology, 2020 - Springer
… collected from hemophilia-specific patient diaries used for home … patterns of hemophilia
treatment, bleeding frequency, and … per patient, the robust sandwich covariance estimate was …

Comprehensive clinical and statistical analysis of hemophilia in Korea

KY Kim, CH Yang, MJ Cho… - Journal of Korean medical …, 1988 - synapse.koreamed.org
… There were known hemophilia patients in the family in 430% … in descending order of frequency.
The major symptoms of the … The financial cost of hemophila, estimated to be in the range …

The growing number of hemophilia registries: quantity vs. quality

C Keipert, J Hesse, B Haschberger… - Clinical …, 2015 - Wiley Online Library
… to optimize treatment, and estimate the balance between the … for prophylactically treated
hemophilia patients, the authors … frequency in PUPs and minimally blood component-treated …

Estimating the risk of thrombotic events in people with congenital hemophilia A using US claims data

I Faghmous, F Nissen, P Kuebler… - Journal of …, 2021 - becarispublishing.com
hemophilia A (PwcHA) to the general non-hemophilia A (HA) population. Patients & … then
randomly selected from the MarketScan database and frequency-matched to the HA cohorts by …

[HTML][HTML] Factor VIII activity and bleeding risk during prophylaxis for severe hemophilia A: a population pharmacokinetic model

A Tiede, FA Karim, V Jiménez-Yuste, R Klamroth… - …, 2021 - ncbi.nlm.nih.gov
… as a measure of bleeding frequency for spontaneous bleeds, … to estimate FVIII levels in
patients with severe hemophilia A … In conclusion, in patients of all ages with severe hemophilia

Occurrence of hemophilia in the United States

…, Hemophilia Surveillance System Project … - American journal of …, 1998 - Wiley Online Library
… Case-finding methods included patient reports from … Patient data from medical care received
during 1993–1994, and, … we wanted to estimate the prevalence of hemophilia in 1994, …