… in reducing the frequency of joint bleeds and hemophilic arthropathy, … estimation with
reduced plasma sampling is considered a more practical and less expensive PK-based estimate …

… corresponding increase in bleeding frequency. Spontaneous joint … of patients with chronic
pain due to hemophilic arthropathy. … not provide a clear estimate of hemophilia-related chronic …

… Accurate estimates of the burden of hemophilia B are important for population health …
with access to prophylaxis, patients with severe hemophilia B remain at considerable risk …

… 2006 estimated that 55% of adults with severe hemophilia A … analysis, we identify patient or
hemophilia-related factors … radiosynovectomy), and a higher frequency of viral co-infections …

… Simulations using the model with various dosing scenarios estimated that > 85% and > 93%
of patients were predicted to maintain FVIII activity level above 1 IU dL −1 , at all times with …

… half-life and the clinical characteristics of patients with severe hemophilia. We found that
shorter … Among these prophylactically treated patients, joint bleed frequency and arthropathy as …

… concentrations and daily bleed frequency. A significant effect of … In the present study, using
a larger patient database, the … records and PK parameter estimates. Any additional effects of …

… All patients with severe hemophilia and all male patients with … Frequencies of F8 and F9
variants by type and hemophilia … underpowered to accurately estimate hemophilia B inhibitor …

… patients with moderate or severe forms of hemophilia fulfilling the recruitment criteria were
included, we could have increased the number of patients with mild hemophilia… point estimate …

… by hemophilia 2 . The prevalence of HA is approximately five times that of HB 3 , with a
worldwide frequency estimated at one … in hemophilia patients, a study of low TFPI in FV‐deficient …