… as phenotypically by the severity and frequency of bleeding patients experienceCitation 3 .
… This study aimed to estimate and compare clinical outcomes, defined as billed annualized …

… to the same dose and dosing frequency of BAY 81-8973. … estimates) indicated a precise
and robust estimation of all model parameters (Fig. 2). The popPK model was used to estimate t …

… meaningful efficacy in preventing or reducing the frequency of bleeding episodes in PwHA
with or … Inter-individual random-effect estimates were compared across the different patient …

… Despite a low frequency of joint bleeds, a substantial proportion of this population presented
… are converted to a nonsevere phenotype with an estimated FVIII level equivalent to >10 IU/dl…

… in patients with severe hemophilia A, in real-world clinical practice the dose and frequency
of … Kaplan-Meier estimated probability of not escalating to the two times a week regimen was …

… frequency of bleeding episodes are related to the level of factor VIII clotting activity. Individuals
with severe hemophilia … known family history of hemophilia. Without prophylactic treatment…

… regimens, causing a decreased frequency of dosing for some, … [rFVIIIFc]) on hemophilic
patients estimated that the expense … the insurance problems that many hemophilic patients have. …

… personalize the dose and frequency of prophylactic treatment … factor VIII (FVIII) trough levels
in patients with hemophilia A. … and estimate the personalized target trough level a patient …

… Sample size estimation was not performed due to the design of the study; therefore, all of …
in both the hemophilia A and hemophilia B patients. Table 3 shows the frequency of switches …

… to provide reliable cost estimates for patients with hemophilia A managed with prophylaxis.
… were summarized as annual frequency of events and annual costs per patient. Descriptive …