[HTML][HTML] Pathogenic mechanisms and therapy development for C9orf72 amyotrophic lateral sclerosis/frontotemporal dementia
… genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
The proposed disease mechanisms include loss of C9orf72 function and gain of toxicity from …
The proposed disease mechanisms include loss of C9orf72 function and gain of toxicity from …
Motor neuron disease and frontotemporal dementia: sometimes related, sometimes not
J Hardy, E Rogaeva - Experimental neurology, 2014 - Elsevier
… separate from those which lead to just one gives a clearer conclusion about disease mechanisms
than … We conclude that the current state of knowledge points to common mechanisms …
than … We conclude that the current state of knowledge points to common mechanisms …
Frontotemporal dementia and tauopathy
Y Yoshiyama, VMY Lee, JQ Trojanowski - Current Neurology and …, 2001 - Springer
… as current understanding of the disease mechanisms underlying them. Although transgenic
… seen in human tauopathies, the precise mechanisms leading to the onset and progression …
… seen in human tauopathies, the precise mechanisms leading to the onset and progression …
Frontotemporal dementia
J Bang, S Spina, BL Miller - The Lancet, 2015 - thelancet.com
… which led to the use of Pick's disease as a synonym for frontotemporal dementia. In 1982,
Mesulam described a language subtype of the disorder, later defined as primary progressive …
Mesulam described a language subtype of the disorder, later defined as primary progressive …
Modelling the pathology and behaviour of frontotemporal dementia
DA Solomon, JC Mitchell… - Neuropathology and …, 2019 - Wiley Online Library
… We discuss the emerging disease pathways that have emerged from these in vivo models
and how this has shaped our understanding of disease mechanisms underpinning FTD. We …
and how this has shaped our understanding of disease mechanisms underpinning FTD. We …
Frontotemporal dementia: implications for understanding Alzheimer disease
M Goedert, B Ghetti… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Frontotemporal dementia (FTD) comprises a group of behavioral, language, and movement
disorders. On the basis of the nature of the characteristic protein inclusions, frontotemporal …
disorders. On the basis of the nature of the characteristic protein inclusions, frontotemporal …
The underlying mechanisms of verbal fluency deficit in frontotemporal dementia and semantic dementia
M Laisney, V Matuszewski, F Mézenge, S Belliard… - Journal of …, 2009 - Springer
… of the cognitive and neural mechanisms underlying verbal fluency impairment in the frontal
variant of frontotemporal dementia (fv-FTD) and in semantic dementia (SD). Semantic and …
variant of frontotemporal dementia (fv-FTD) and in semantic dementia (SD). Semantic and …
Distinct neuroanatomical substrates and cognitive mechanisms of figure copy performance in Alzheimer's disease and behavioral variant frontotemporal dementia
KL Possin, VR Laluz, OZ Alcantar, BL Miller… - Neuropsychologia, 2011 - Elsevier
… of figure copy performance in 46 patients with Alzheimer's disease (AD) and 48 patients
with the behavioral variant of Frontotemporal dementia (bvFTD). A group of 94 neurologically …
with the behavioral variant of Frontotemporal dementia (bvFTD). A group of 94 neurologically …
[HTML][HTML] Tau-mediated dysregulation of RNA: Evidence for a common molecular mechanism of toxicity in frontotemporal dementia and other tauopathies
SA Koren, S Galvis-Escobar, JF Abisambra - Neurobiology of disease, 2020 - Elsevier
… Frontotemporal dementias (FTDs) encompass several disorders commonly characterized by
progressive frontotemporal lobar degeneration and dementia… The complex mechanisms that …
progressive frontotemporal lobar degeneration and dementia… The complex mechanisms that …
Frontotemporal dementia: latest evidence and clinical implications
JJ Young, M Lavakumar, D Tampi… - Therapeutic …, 2018 - journals.sagepub.com
Background: Frontotemporal dementia (FTD) describes a cluster of neurocognitive
syndromes that present with impairment of executive functioning, changes in behavior, and a …
syndromes that present with impairment of executive functioning, changes in behavior, and a …