[HTML][HTML] Pathogenic mechanisms and therapy development for C9orf72 amyotrophic lateral sclerosis/frontotemporal dementia

J Jiang, J Ravits - Neurotherapeutics, 2019 - Elsevier
… genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
The proposed disease mechanisms include loss of C9orf72 function and gain of toxicity from …

Motor neuron disease and frontotemporal dementia: sometimes related, sometimes not

J Hardy, E Rogaeva - Experimental neurology, 2014 - Elsevier
… separate from those which lead to just one gives a clearer conclusion about disease mechanisms
than … We conclude that the current state of knowledge points to common mechanisms

Frontotemporal dementia and tauopathy

Y Yoshiyama, VMY Lee, JQ Trojanowski - Current Neurology and …, 2001 - Springer
… as current understanding of the disease mechanisms underlying them. Although transgenic
… seen in human tauopathies, the precise mechanisms leading to the onset and progression …

Frontotemporal dementia

J Bang, S Spina, BL Miller - The Lancet, 2015 - thelancet.com
… which led to the use of Pick's disease as a synonym for frontotemporal dementia. In 1982,
Mesulam described a language subtype of the disorder, later defined as primary progressive …

Modelling the pathology and behaviour of frontotemporal dementia

DA Solomon, JC Mitchell… - Neuropathology and …, 2019 - Wiley Online Library
… We discuss the emerging disease pathways that have emerged from these in vivo models
and how this has shaped our understanding of disease mechanisms underpinning FTD. We …

Frontotemporal dementia: implications for understanding Alzheimer disease

M Goedert, B Ghetti… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Frontotemporal dementia (FTD) comprises a group of behavioral, language, and movement
disorders. On the basis of the nature of the characteristic protein inclusions, frontotemporal

The underlying mechanisms of verbal fluency deficit in frontotemporal dementia and semantic dementia

M Laisney, V Matuszewski, F Mézenge, S Belliard… - Journal of …, 2009 - Springer
… of the cognitive and neural mechanisms underlying verbal fluency impairment in the frontal
variant of frontotemporal dementia (fv-FTD) and in semantic dementia (SD). Semantic and …

Distinct neuroanatomical substrates and cognitive mechanisms of figure copy performance in Alzheimer's disease and behavioral variant frontotemporal dementia

KL Possin, VR Laluz, OZ Alcantar, BL Miller… - Neuropsychologia, 2011 - Elsevier
… of figure copy performance in 46 patients with Alzheimer's disease (AD) and 48 patients
with the behavioral variant of Frontotemporal dementia (bvFTD). A group of 94 neurologically …

[HTML][HTML] Tau-mediated dysregulation of RNA: Evidence for a common molecular mechanism of toxicity in frontotemporal dementia and other tauopathies

SA Koren, S Galvis-Escobar, JF Abisambra - Neurobiology of disease, 2020 - Elsevier
Frontotemporal dementias (FTDs) encompass several disorders commonly characterized by
progressive frontotemporal lobar degeneration and dementia… The complex mechanisms that …

Frontotemporal dementia: latest evidence and clinical implications

JJ Young, M Lavakumar, D Tampi… - Therapeutic …, 2018 - journals.sagepub.com
Background: Frontotemporal dementia (FTD) describes a cluster of neurocognitive
syndromes that present with impairment of executive functioning, changes in behavior, and a …