… This review focuses on mechanisms that regulate PGRN levels in different brain cells,
how PGRN regulates the clearance of disease-causing proteins from neurons to impact …

… Although MAPT- and PGRN-gene-associated FTD were reported on occasion to show
ALS features, the real breakthrough linking ALS and FTD disease mechanisms came with the …

… In frontotemporal dementia (FTD) there is a critical lack in the understanding of biological and
molecular mechanisms involved in disease … that multiple disease-mechanisms are likely to …

… of Alzheimer disease (AD), much insight has been gained regarding the mechanisms leading
to … The study of these genes has dramatically altered our understanding of the mechanisms …

… have been linked to Alzheimer's disease (AD) and frontotemporal dementia (FTD). Recent
… that may interfere with essential cellular mechanisms at an early disease stage. This review …

… We reviewed current knowledge on causative genes and altered mechanisms leading to the
two diseases, genetic risk factors and disease modifiers shown to influence the age at onset …

… of frontotemporal dementia (fv-FTD). The aim of this study was therefore to unravel the
mechanisms … in fv-FTD, and suggest that the mechanisms at the root of autobiographical memory …

… The aim of this study was to investigate two putative pathophysiological aspects of the
common neurodegenerative disorder frontotemporal dementia (FTD). To this end, cerebrospinal …

… inclusions in the brains of patients with frontotemporal dementias (FTD-U) and amyotrophic
… IBM), Paget’s disease of the bone and frontotemporal dementia (IBMPFD) has ubiquitinated …

… The prototypical clinical syndromes are behavioural variant frontotemporal dementia (bvFTD…
), a disorder of expressive language, and semantic dementia (SD), a disorder of conceptual …