Treating life-threatening myocarditis by blocking interleukin-1

G Cavalli, F Pappalardo, A Mangieri… - Critical Care …, 2016 - journals.lww.com
… Treatment of viral fulminant myocarditisinterleukin-1 in myocardial inflammation and
contractile dysfunction, we treated a patient with fulminant viral myocarditis with the interleukin-1

Interleukin-1 receptor blockade rescues myocarditis-associated end-stage heart failure

G Cavalli, M Foppoli, L Cabrini, CA Dinarello… - Frontiers in …, 2017 - frontiersin.org
… -1 blockade in a case of fulminant myocarditis. The patient had developed fulminant myocarditis
… treatment options for fulminant myocarditis beyond mechanical support, we evaluated IL-…

[HTML][HTML] Myocarditis: an interleukin-1-mediated disease?

G De Luca, G Cavalli, C Campochiaro… - Frontiers in …, 2018 - frontiersin.org
… This direct beneficial effect of IL-1 inhibition on contractile function explains in part the
near-instant clinical improvement observed in life-threatening cases of fulminant myocarditis, …

Serum levels of interleukin-10 on admission as a prognostic predictor of human fulminant myocarditis

M Nishii, T Inomata, H Takehana, I Takeuchi… - Journal of the American …, 2004 - jacc.org
… Table 1shows the individual baseline data of patients with fulminant myocarditis included
in this study. A viral study was performed in nine patients by measurement of neutralizing …

Anakinra in pediatric acute fulminant myocarditis

L Maunier, R Charbel, V Lambert, P Tissières - Annals of Intensive Care, 2022 - Springer
… biological activity of interleukin-1 alpha and beta (IL-1ß) by competitive inhibition of IL-1
binding to … Thus we report our experience of eight children with acute fulminant myocarditis who …

[HTML][HTML] Fulminant myocarditis due to COVID-19

A Irabien-Ortiz, J Carreras-Mora, A Sionis… - Revista espanola de …, 2020 - ncbi.nlm.nih.gov
… -19 have high concentrations of interleukin (IL)-1 beta, interferon (IFN) gamma, IFN-inducible
protein (IP)-10, and monocyte chemoattractant protein (MCP)-1. It has been shown that …

[HTML][HTML] Interleukin-10: biomarker or pathologic cytokine in fulminant myocarditis?

KU Knowlton, T Yajima - Journal of the American College of Cardiology, 2004 - jacc.org
fulminant myocarditis. These findings indicate that IL-10 might be a useful prognostic marker
in patients with fulminant myocarditis, … in patients with fulminant myocarditis than in severely …

Pathogenic pathways and therapeutic targets of inflammation in heart diseases: A focus on Interleukin1

MG Del Buono, A Bonaventura… - European Journal of …, 2024 - Wiley Online Library
… Anakinra has shown to improve cardiac function in case reports of patients with fulminant
myocarditis.ARAMIS (Anakinra Versus Placebo for the Treatment of Acute Myocarditis) is the …

Fulminant myocarditis

F Ginsberg, JE Parrillo - Critical care clinics, 2013 - criticalcare.theclinics.com
… Direct cytolysis of myocytes caused by the initial viral infection in stage 1 is thought to be
particularly important in fulminant myocarditis. Early and extensive loss of myocytes and …

Fulminant Type 1 Diabetes Mellitus and Fulminant Viral Myocarditis A Case Report and Literature Review

N Ohara, M Kaneko, H Kuwano, K Ebe… - International heart …, 2015 - jstage.jst.go.jp
… of concurrent FT1D and fulminant viral myocarditis. Parainfluenza-… and fulminant myocarditis.
(Int Heart J 2015; 56: 239-244) … Interleukin-6 and viral myocarditis: the Yin-Yang of cardiac …