Functional analysis of tumor necrosis factor (TNF) receptors in TNF-α-mediated insulin resistance in genetic obesity

KT Uysal, SM Wiesbrock, GS Hotamisligil - Endocrinology, 1998 - academic.oup.com
Tumor necrosis factor-α (TNF-α) is overexpressed in obesity … of TNF-α function through
targeted mutations in TNF-α gene … have analyzed the in vivo role of TNF signaling from p55 [TNF

Functional Analysis of a New Polymorphism in the Human TNF α Gene Promoter.

F Pociot, S D'Alfonso, S Compasso… - Scandinavian …, 1995 - search.ebscohost.com
In this paper the functional relevance of a TNFA promoter polymorphism, a G/A polymorphic
sequence at position-238, was tested by analysing its influence on TNFα production upon in …

Functional Analysis of a Human Tumor Necrosis Factor α (TNF-α) Promoter Polymorphism Related to Joint Damage in Rheumatoid Arthritis

EL Kaijzel, MV van Krugten, BMN Brinkman… - Molecular …, 1998 - Springer
Functional heterogeneity in the tumor necrosis factor α (TNF-α) gene may be responsible
for the TNF-α … Recently, the TNF-238 promoter polymorphism was observed as being …

Functional analysis of the domain structure of tumor necrosis factor-α converting enzyme

P Reddy, JL Slack, R Davis, DP Cerretti… - Journal of Biological …, 2000 - ASBMB
… with TACE and substrate cDNAs to study TACE function and regulation. Using the TACE-…
family member, ADAM-10, we studied the function of the different domains of TACE in three …

Characterization and functional analysis of goldfish (Carassius auratus L.) tumor necrosis factor-alpha

L Grayfer, JG Walsh, M Belosevic - Developmental & Comparative …, 2008 - Elsevier
… Here we report the molecular characterization of two goldfish TNFα isoforms and functional
analysis of goldfish TNFα-2. The quantitative PCR analysis indicated that the two isoforms of …

[HTML][HTML] Structure–function analysis of an evolutionary conserved protein, DAP3, which mediates TNFα‐and Fas‐induced cell death

JL Kissil, O Cohen, T Raveh, A Kimchi - The EMBO journal, 1999 - embopress.org
… Here we report on the structure–function analysis of DAP3 protein. We provide a few … is
involved in TNFα‐ and Fas‐induced cell death, thus indicating that the function of this gene in …

Functional analysis of linker-scan mutants spanning the− 376,− 308,− 244, and− 238 polymorphic sites of the TNF-α promoter

JP Bayley, H de Rooij, PJ van Den Elsen… - Cytokine, 2001 - Elsevier
… scan analysis of the TNF-α promoter 376 region To explore the functional relevance of TNF-α
… polymorphic positions we generated linker-scan mutants in the TNF-α promoter segment …

Generation and functional analysis of human TNFα/iNOS‐producing dendritic cells (T ip‐DC)

D Wilsmann‐Theis, S Koch, C Mindnich, S Bonness… - Allergy, 2013 - Wiley Online Library
… of tumor necrosis factor ( TNF )‐α and inducible NO synthase ( iNOS ), these cells have been
referred to as TNF … of infection, functional data about their human counterpart are lacking. …

A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

T Bouwmeester, A Bauch, H Ruffner, PO Angrand… - Nature cell …, 2004 - nature.com
… of the TNF-α/NF-κB pathway through an integrated approach of proteomic pathway mapping
based on established components and their paralogues, and on functional analysis with …

Association of tumor necrosis factor receptor type II polymorphism 196R with Systemic lupus erythematosus in the Japanese: molecular and functional analysis

C Morita, T Horiuchi, H Tsukamoto… - … : Official Journal of …, 2001 - Wiley Online Library
… of tumor necrosis factor α (TNFα) in the development of autoimmunity has been suggested.
TNFα … In humans, a polymorphism in the promoter region of the TNFα gene (TNFα-308A) has …