… for the identification of compounds with allosteric modulatory effects on neurotransmitter
receptors such as the nAChR, even when employed with relatively small compound libraries. …

… Genes functionally characterised in this work are shown in bold. The values in the colour
bar are log-transformed values of relative transcript levels (2 −∆Ct ) determined by quantitative …

… study was to analyse these gene variants for their functionality and to predict the tertiary
structure of the protein in order to correlate the functional differences with the protein structure. …

… Here, we describe the current knowledge of the structures and properties of protein–protein
interactions and the small molecules that can modulate them. We then describe the use of …

… functions were characterised that integration of expression cassettes occurred randomly.
Random insertion of a cassette may disrupt gene expression and/or protein functions and …

… architecture, polarity and function, making it no surprise that many proteins of the secretory
… a functional characterisation of the Saccharomyces cerevisiae cell polarity protein and …

… using recombinant protein. In addition, the recombinant UGP was kinetically characterised
and its … Since the functionality of these proteins is highly conserved, the complementation …

… (A) Functional characterisation of the best Blastx hits obtained for the end-sequences of
BAC clones, distribution into functional categories given in %. (B) Representative physical map …

… to varying the functional groups on the phenol, allowing for variation within the library whilst
retaining the core scaffold. In this thesis, the bioactivity of this novel benzopyran library was …

… To characterise this phenomenon in more detail, we next performed 2D-gelelectrophoresis
in which the proteins were separated on IPG strips according to their isoelectric points (1D) …