… What causes heartburn in these patients is unclear. In this study, we evaluated esophageal
sensitivity and esophageal mucosal barrier function of patients with functional heartburn. …

… hypersensitivity in FH, including new findings on the mechanisms of esophageal sensitivity
and the manifestations of heartburn symptoms. There are currently many unmet clinical …

… to esophageal balloon distention, intraesophageal acid … that patients with functional
heartburn are more sensitive to … esophageal sensitivity in patients with functional heartburn …

… the acid-sensitive esophagus … esophageal sphincter relaxations with agents such as baclofen
is being investigated. Antireflux surgery in patients with functional heartburn and non–acid …

… those with functional heartburn is their sensitivity to … sensitive to physiologic levels of acidic
reflux. The introduction of the pH-impedance test revealed esophageal sensitivity to non-acid …

… chronically using antacids for heartburn had esophageal sensitivity to mechanical or chemical
… subset of typical heartburn sufferers have a lower threshold for esophageal sensation and …

… acid-hypersensitive esophagus, or to a non-acid factor in the refluxate triggering symptoms.
… sensitivity to acid infusion has been demonstrated in patients with acidsensitive esophagus […

… opposed to NERD, are not really evident once patients with acid-sensitive esophagus have
… patients with mechanical sensitivity and overlapping symptoms of functional heartburn and …

… They found that proximal esophagus was more sensitive and sensitivity … and functional
heartburn, we showed that the prevalence of major depressive disorder in functional heartburn (…

… Functional heartburn patients demonstrate traits of functional … lack a uniform increase of
chemoreceptor sensitivity to acid. … in functional heartburn; for example, although esophageal-…