… defined by endoscopy-negative heartburn with a normal acid … Functional heartburn (FH) is
distinguished by negative SAP/… investigate whether impairment of chemical clearance and of …

… is relevant to the pathogenesis of mucosal damage in GERD and suggest that these new
parameters may contribute to distinguish hypersensitive oesophagus from functional heartburn. …

… , functional heartburn [ 4 ] and also to investigate the mechanisms of PPI refractoriness [ 2,
3 ]. By impedance-pH monitoring it has long been recognized that PPIs transform the majority …

… be associated with chemical clearance dysfunction as measured … In this study, functional
heartburn was diagnosed in the … GERD and those with functional heartburn, because the normal …

… functional heartburn (FH), the former defined as the presence of typical symptoms of GERD
caused by reflux in the absence of visible esophageal mucosal injury at endoscopy6 and the …

… disorder than was originally thought. First, it is known that almost two-thirds of those with
typical … In contrast, PSPW, a marker of chemical clearance, is defined as an antegrade 50% …

… baseline impedance (MNBI), and the chemical clearance, through the assessment of the post
… reflux is associated with greater impairment of mucosal integrity and chemical clearance. …

… Thus, these results underline that esophageal mucosal integrity is strictly related to the
efficacy of chemical clearance and then confirm that impaired esophageal chemical clearance …

… with heartburn but no pathophysiological characteristics of GERD (functional heartburn, FH
… [11]: this suggests that impaired chemical clearance can be a primary pathophysiological …

… indicating impairment of esophageal chemical clearance and … PSPWI predicted esophageal
chemical clearance and MNBI … of PSPWI and MNBI than functional heartburn (FH) patients. …