Refractory gastroesophageal reflux disease and functional heartburn
SJ Spechler - Gastrointestinal Endoscopy Clinics, 2020 - giendo.theclinics.com
… In 1 study of patients with PPI-refractory GERD symptoms on twice-daily PPIs, abnormal
esophageal acid exposure was found in only 7% of 52 patients with typical GERD …
esophageal acid exposure was found in only 7% of 52 patients with typical GERD …
Patients with refractory reflux symptoms: What do they have and how should they be managed?
PJ Kahrilas, L Keefer… - Neurogastroenterology & …, 2015 - Wiley Online Library
… This review discusses potential etiologies for PPI-refractory symptoms. Three major … So
what then is the explanation of symptom genesis in functional heartburn if not from reflux? …
what then is the explanation of symptom genesis in functional heartburn if not from reflux? …
Functional heartburn
R Dickman, R Fass - Current Treatment Options in Gastroenterology, 2005 - Springer
… PPI, but one study has demonstrated that symptom resolution is reported by only 25% of these
patients [22]. The causes of refractory GERD symptoms … patients’ heartburn symptoms. By …
patients [22]. The causes of refractory GERD symptoms … patients’ heartburn symptoms. By …
Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors
D Sifrim, F Zerbib - Gut, 2012 - gut.bmj.com
… Functional heartburn is one of the most common causes for failure of PPI treatment. The
underlying mechanisms for symptoms in functional heartburn patients remain to be elucidated. …
underlying mechanisms for symptoms in functional heartburn patients remain to be elucidated. …
Management of patients with functional heartburn
… MNBI is lower among PPI-responsive than PPI-refractory functional heartburn. … rate beyond
50% in true functional heartburn unless if functional heartburn overlaps with GERD. For the …
50% in true functional heartburn unless if functional heartburn overlaps with GERD. For the …
Refractory heartburn: a challenging problem in clinical practice
G Domingues, JPP Moraes-Filho, R Fass - Digestive diseases and …, 2018 - Springer
… of symptom generation in functional heartburn is complex and … of the patients referred with
refractory heartburn do not have … refractory heartburn and/or regurgitation symptoms on PPI …
refractory heartburn do not have … refractory heartburn and/or regurgitation symptoms on PPI …
AGA clinical practice update on functional heartburn: expert review
R Fass, F Zerbib, CP Gyawali - Gastroenterology, 2020 - Elsevier
… esophageal testing to differentiate functional heartburn from refractory reflux disease. Studies
… Antireflux medications, specifically PPIs, have no therapeutic role in functional heartburn, …
… Antireflux medications, specifically PPIs, have no therapeutic role in functional heartburn, …
[HTML][HTML] Current diagnosis and management of suspected reflux symptoms refractory to proton pump inhibitor therapy
JE Richter - Gastroenterology & Hepatology, 2014 - ncbi.nlm.nih.gov
… functional heartburn, a visceral hypersensitivity syndrome. Treating patients with PPI-refractory
GERD–like symptoms … with PPI-refractory symptoms. Helpful clues include the associated …
GERD–like symptoms … with PPI-refractory symptoms. Helpful clues include the associated …
Prevalence of gastroesophageal reflux disease and proton pump inhibitor-refractory symptoms
… Therefore, the aims of this study were to determine the prevalence and predictors of
GERD and PPI-refractory GERD symptoms in a large, representative sample of community-dwelling …
GERD and PPI-refractory GERD symptoms in a large, representative sample of community-dwelling …
Refractory GERD, beyond proton pump inhibitors
… Nine hypothetical scenario of patients with proven GERD off PPI and persistent symptoms
on PPI were discussed by 14 American expert esophagologists in a three rounds process to …
on PPI were discussed by 14 American expert esophagologists in a three rounds process to …
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