… Functional heartburn is common and is likely to affect a large subset of patients presenting …
progression of functional heartburn to nonerosive reflux disease (NERD), erosive esophagitis, …

… , patients with an acid-hypersensitive esophagus (ie, > 50% of the symptomatic episodes …
acid reflux), patients with functional heartburn (symptoms that are independent of acid reflux …

… GERD can be complicated by reflux esophagitis and peptic esophageal strictures, which
occasionally can be difficult to treat and hence might be considered refractory. Patients …

… compared with patients with NERD or erosive esophagitis. … can differentiate between GERD
and functional heartburn by … GERD but are not found in patients with functional heartburn. …

… Souza and colleagues, using a rat model of reflux esophagitis, put forth the idea that acid
does not directly injure the esophageal mucosal epithelium, but rather that esophageal …

… GERD phenotypes and functional heartburn, we showed that the prevalence of major depressive
disorder in functional heartburn … both NERD and erosive esophagitis patients (Table 3) […

… functional heartburn or reflux hypersensitivity overlapping with gastroesophageal reflux disease
(GERD… and eosinophilic esophagitis may be responsible for chronic heartburn symptoms…

… By definition, there should be no link between reflux and symptoms in functional heartburn.
… evidence of pathologic gastroesophageal reflux (ie, significant peptic esophagitis, Barrett’s …

… endoscopy, normal oesophageal acid exposure, no symptom-reflux association and who …
functional heartburn (FH). This study aimed (i) to characterize the symptoms and functional …

… When esophageal acid exposure time (AET) is physiologic, ROME … functional esophageal
disorders into functional heartburn (FH, with negative reflux‐symptom association) and reflux …