Since the first report in early 1990s, mesoporous silica nanoparticles (MSNs) have
progressively attracted the attention of scientists due to their potential applications in physic,
energy storage, imaging, and especially in biomedical engineering. Owning the unique
physiochemical properties, such as highly porosity, large surface area and pore volume,
functionalizable, tunable pore and particle sizes and biocompatibility, and high loading
cavity, MSNs offer efficient encapsulation and then controlled release, and in some cases …

The application of nanomedicines in tumor targeting and attaining meaningful therapeutic
benefits for the treatment of cancers has been going on for almost two decades. Beyond the
lipidic and polymeric nanomedicines-based passive and active targeting, the quest for
inventing the new generation of carriers has no end. This has lead to the evolution of some
of the unique carrier systems with supramolecular assembly structures. Mesoporous
nanoparticulate systems (MSNPs) are the recently explored substances with favorable …