The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance

S Winer, DA Winer - Immunology and cell biology, 2012 - Wiley Online Library
… decade, chronic inflammation in visceral adipose tissue (VAT… tissue macrophages, in the
regulation of fat inflammation and … the extent of the local inflammatory response, thereby directly …

Tissue homeostasis and inflammation

ML Meizlish, RA Franklin, X Zhou… - Annual review of …, 2021 - annualreviews.org
… We can understand this fundamental organization by considering … tissue disruption caused
by the inflammatory triggers. In addition to regulating effector functions specific to inflammation

Regulation of tissue homeostasis by NF-κB signalling: implications for inflammatory diseases

M Pasparakis - Nature Reviews Immunology, 2009 - nature.com
… pathogenesis of several inflammatory diseases and cancer. NF-κB promotes inflammation
and immunity against pathogens by regulating the expression of pro-inflammatory molecules, …

Inflammation and metabolism in tissue repair and regeneration

SA Eming, TA Wynn, P Martin - Science, 2017 - science.org
… At a fundamental cell biology level, we know that immune cells respond to attractant cues
through Rho family small guanosine triphosphatase (GTPase) regulation of their actin …

Origin and physiological roles of inflammation

R Medzhitov - Nature, 2008 - nature.com
… roots of inflammation as an adaptive response to tissue … of inflammatory inducer, including
altered cellular and tissue … in lethal inflammation in the absence of a negative regulator of TLR …

Regulation of inflammation by PPARs: a future approach to treat lung inflammatory diseases?

J Becker, C Delayre‐Orthez… - Fundamental & clinical …, 2006 - Wiley Online Library
… PPARγ, have been implicated in the regulation of inflammation, including the lung. The present
inflammation, and of their potential as novel targets for the treatment of lung inflammatory

Transcriptional control of the inflammatory response

R Medzhitov, T Horng - Nature Reviews Immunology, 2009 - nature.com
Inflammation is a fundamental adaptation to the loss of cellular and tissue homeostasis with
… Therefore, much of this Review focuses on the transcriptional regulation of inflammation by …

Systems biology of adipose tissue metabolism: regulation of growth, signaling and inflammation

S Manteiga, K Choi, A Jayaraman… - … : Systems Biology and …, 2013 - Wiley Online Library
… Discoveries of AT-derived hormones with systemic effects, notably leptin,3 have fundamentally
redefined the physiological role of the tissue as an active site of metabolic control for the …

pH sensing at the intersection of tissue homeostasis and inflammation

S Hajjar, X Zhou - Trends in Immunology, 2023 - cell.com
… Leveraging the knowledge of human physiology and regulation … novel framework of tissue
homoeostasis and inflammation [ … regulation may offer valuable insights into the fundamental

The intrinsic and extrinsic elements regulating inflammation

M Mollaei, A Abbasi, ZM Hassan, N Pakravan - Life Sciences, 2020 - Elsevier
… Altogether, diet and feeding have a fundamental impact on inflammatory and immune
responses. Studies show a physiological increase in the level of IL-1β after feeding even in thin …