Peripheral galanin receptor 2 as a target for the modulation of pain

RP Hulse, LF Donaldson… - Pain research and …, 2012 - Wiley Online Library
… of galanin receptors on primary afferent nociceptors as … galanin receptors in the central
nervous system, functional studies demonstrated that galanin could modulate spinal nociceptive

[HTML][HTML] A new gal in town: a systematic review of the role of galanin and its receptors in experimental pain

D Fonseca-Rodrigues, A Almeida, F Pinto-Ribeiro - Cells, 2022 - mdpi.com
… The role of galanin in nociceptive modulation has been intensively investigated using …
insufficient galaninergic control of nociception, targeting galanin receptors (particularly GalR1) …

Activation of peripheral galanin receptors: differential effects on nociception

JM Jimenez-Andrade, L Lundström… - Pharmacology …, 2006 - Elsevier
… To determine if high doses of peripheral GAL modulated CAP-induced nociception, male
Wistar rats received intraplantar injections of 10 μl 0.1% CAP + 20 μl saline or 10 μl 0.1% CAP …

[HTML][HTML] Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats

SY Li, ML Huo, XY Wu, YQ Huang, L Wang, X Zhang… - Scientific Reports, 2017 - nature.com
… the role of galanin and galanin receptor 1 (GalR 1) in nociceptive modulation in the central
… -dependent manner after intra-CeA injection of galanin in both normal rats and rats with …

Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor

RP Hulse, LF Donaldson, D Wynick - Molecular Pain, 2012 - journals.sagepub.com
… Mechanically evoked responses in C-fibre nociceptors from naive rats … galanin or Gal2-11
(a galanin receptor-2/3 agonist) confirming previous data that galanin modulates nociception

Pro-nociceptive role of peripheral galanin in inflammatory pain

JM Jimenez-Andrade, S Zhou, J Du, A Yamani… - Pain, 2004 - Elsevier
… In summary, our findings suggest that peripheral GAL modulates VR1 function and has
an excitatory role under acute inflammatory conditions. This excitatory effect is likely to be …

Galanin plays a role in antinociception via binding to galanin receptors in the nucleus accumbens of rats with neuropathic pain

Y Zhang, Y Gao, CY Li, W Dong, MN Li, YN Liu… - Neuroscience …, 2019 - Elsevier
Galanin and galanin receptors (GalRs) play important roles in the transmission and
modulation of nociceptive information. Our previous research has shown that the expression of …

[PDF][PDF] Galanin receptor 1 plays an antinociceptive effect via inhibiting PKA activation in the nucleus accumbens of rats with neuropathic pain

Y Zhang, Y Gao, CY Li, W Dong, Y Dong… - Physiological …, 2019 - biomed.cas.cz
… ZHANG ML, WANG HB, FU FH, YU LC: Involvement of galanin and galanin receptor 2 in
nociceptive modulation in anterior cingulate cortex of normal rats and rats with mononeuropathy…

Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia

RP Hulse, D Wynick, LF Donaldson - Molecular pain, 2011 - journals.sagepub.com
… the anti-nociceptive actions of galanin are principally … by each galanin receptor subtype
in nociceptive processing in … activation of GalR2 can modulate nociceptive C-fibre afferent …

Interactions of galanin and opioids in nociceptive modulation in the arcuate nucleus of hypothalamus in rats

YG Sun, LC Yu - Regulatory peptides, 2005 - Elsevier
galanin in a dose-dependent manner, while the δ-opioid receptor antagonist naltrindole or
the κ-opioid receptor … Moreover, intra-ARC injection of a galanin receptor antagonist galantide …