Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour

TJS Shi, X Hua, X Lu, S Malkmus… - European Journal of …, 2006 - Wiley Online Library
… It affects pain threshold and has developmental and trophic effects. Galanin acts at three
G‐protein‐coupled receptors, galanin receptors (GalR1–3), each expressed in the DRGs as …

Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain‐like behaviour

SA Hobson, FE Holmes, NCH Kerr… - Journal of …, 2006 - Wiley Online Library
galanin knockout (Gal‐KO) mice have a developmental loss of a subset of DRG neurons.
Galanin … marked deficits in neuropathic and inflammatory pain behaviours. Adult GalR2‐MUT …

Peripheral galanin receptor 2 as a target for the modulation of pain

RP Hulse, LF Donaldson… - Pain research and …, 2012 - Wiley Online Library
… sensitisation in altered pain behaviours consequent to nerve injury, and also because
peripheral sensitisation has long been thought to contribute little to neuropathic pain. Recently, …

Galanin plays a role in antinociception via binding to galanin receptors in the nucleus accumbens of rats with neuropathic pain

Y Zhang, Y Gao, CY Li, W Dong, MN Li, YN Liu… - Neuroscience …, 2019 - Elsevier
… into the central nucleus of the amygdala [2], the anterior cingulate cortex [3] and the
dorsomedial nucleus of the hypothalamus [4] decreases pain-related behaviours. Our previous …

A new gal in town: a systematic review of the role of galanin and its receptors in experimental pain

D Fonseca-Rodrigues, A Almeida, F Pinto-Ribeiro - Cells, 2022 - mdpi.com
… that intrathecal administration of the putative galanin receptor antagonist M35 (galanin-(1–13)-…
of exogenous galanin on nociception is inhibitory, with several behaviour studies showing …

Hyperalgesia and increased neuropathic pain-like response in mice lacking galanin receptor 1 receptors

KH Blakeman, JX Hao, XJ Xu, AS Jacoby, J Shine… - Neuroscience, 2003 - Elsevier
… The effect of galanin is mediated by at least three subtypes of receptors. In the present study…
galanin receptor 1 gene (Galr1) and the development of neuropathic pain-like behaviours

[HTML][HTML] … the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain

FE Holmes, N Kerr, YJ Chen, P Vanderplank… - Molecular and Cellular …, 2017 - Elsevier
… Measures of acute, inflammatory and neuropathic pain behaviours were not significantly …
galanin receptor subtypes and 20-fold higher than the top of the dose-response curve for each …

A role of supraspinal galanin in behavioural hyperalgesia in the rat

D Amorim, A David-Pereira, P Marques, S Puga… - PLoS …, 2014 - journals.plos.org
… of supraspinal galanin to pain … in galanin receptors (GALR) and is involved in behavioural
hyperalgesia. In this study, we evaluated the contribution of supraspinal GAL to behavioural

Activation of peripheral galanin receptors: differential effects on nociception

JM Jimenez-Andrade, L Lundström… - Pharmacology …, 2006 - Elsevier
… Numerous reports suggest a significant role of peripheral galanin (GAL) in pain transmission…
galanin receptor agonists and antagonists, the role of GAL receptors (GalR1-3) in pain

[PDF][PDF] Galanin receptor 1 plays an antinociceptive effect via inhibiting PKA activation in the nucleus accumbens of rats with neuropathic pain

Y Zhang, Y Gao, CY Li, W Dong, Y Dong… - Physiological …, 2019 - biomed.cas.cz
… the antinociception induced by galanin receptor 1 (GalR1) via … ) of rats with neuropathic
pain. A mononeuropathy model was … the pain behaviour in rats with bone cancer-induced pain (…