Galanin receptor antagonists: a potential novel pharmacological treatment for mood disorders

SO Ögren, E Kuteeva, T Hökfelt, J Kehr - CNS drugs, 2006 - Springer
… of galanin in the rat increases depression-like behaviour, and this is fully blocked by the
nonselective peptide galanin receptor … , pain processing, feeding, sexual behaviour, fear-related …

Galanin receptor 2 is involved in galanin-induced analgesic effect by activating PKC and CaMKII in the nucleus accumbens of inflammatory pain rats

M Li, X Zhang, C Li, Y Liu, S Yang, S Xu - Frontiers in Neuroscience, 2021 - frontiersin.org
galanin was blocked partially by GALR2 antagonist M871, implying that galanin in NAc has
an analgesic effect on inflammatory pain … of GALR2 on inflammatory pain, the GALR2 agonist …

Involvement of galanin in nociceptive regulation in the arcuate nucleus of hypothalamus in rats with mononeuropathy

XL Gu, YG Sun, LC Yu - Behavioural brain research, 2007 - Elsevier
… injection of the putative antagonist of galanin receptors markedly reduced the HWLs. The …
antinociceptive effect of intra-ARC injection of galanin in rats with chronic neuropathic pain. …

Galanin-expression and galanin-dependent sensory neurons are not required for itch

FE Holmes, P Vanderplank, D Wynick - Molecular Pain, 2012 - journals.sagepub.com
… endogenous levels of galanin are high, the neuropeptide inhibits pain behaviour [18,19].
Galanin also plays a developmental cell survival role in the DRG. In the absence of galanin, a …

Galanin receptor-expressing dorsal horn neurons: role in nociception

LL Lemons, RG Wiley - Neuropeptides, 2011 - Elsevier
Galanin, along with enkephalins and neuropeptide Y, has been hypothesized to negatively
modulate nociception in the superficial dorsal horn of the spinal cord. In the present study, …

The neuropeptides Galanin and Galanin (1–15) in depression-like behaviours

C Millón, A Flores-Burgess, M Narváez… - Neuropeptides, 2017 - Elsevier
Galanin but also Galanin N-terminal fragments like Galanin(1… Galanin and Galanin(1–15)
in depression-related behaviours. … through 5-HT1A, and Galanin receptors interact at both pre-…

Galanin–25 years with a multitalented neuropeptide: Galanin and spinal pain mechanisms: Where do we stand in 2008?

XJ Xu, T Hökfelt, Z Wiesenfeld-Hallin - Cellular and Molecular Life …, 2008 - Springer
… recognition and agonist activity at all three subtypes of galanin receptors [13, 36]. Moreover,
… potentiates the spinal analgesic effect of morphine: electrophysiological and behavioural

[PDF][PDF] A New Gal in Town: A Systematic Review of the Role of Galanin and Its Receptors in Experimental Pain. Cells 2022, 11, 839

D Fonseca-Rodrigues, A Almeida, F Pinto-Ribeiro - 2022 - academia.edu
… of the putative galanin receptor antagonist M35 (galanin-(1–13)-… neurons and impaired
pain-like behaviour. J. Neurochem. … ganglion neurone development and pain behaviour. Eur. J. …

Galanin negatively modulates opiate withdrawal via galanin receptor 1

FE Holmes, A Armenaki, TP Iismaa, EB Einstein… - …, 2012 - Springer
… to determine which galanin receptor subtype mediates the actions of galanin on morphine …
a functional GalR1 (galanin receptor 1 mutant (GalR1 mut)) or GalR2 (galanin receptor 2 mut(…

Galanin–25 years with a multitalented neuropeptide: Galanin, galanin receptors and drug targets

K Mitsukawa, X Lu, T Bartfai - Cellular and Molecular Life Sciences, 2008 - Springer
… by galanin acting at GalR2 receptors has also been found. Galanin and galanin receptor
outgrowth from adult sensory neurons and impaired pain-like behaviour. J. Neurochem. …