… whether the gallium-transferrin complex could be effectively used as a macromolecular
tracer in … Three gallium-plasma preparations were tested and 2 h biodistribution studies were …

… that iron, indium, and gallium in tracer amounts were quickly and almost completely bound
to plasma proteins or formed macromolecular aggregates. The retention fraction ofthe [Fe3], […

… of gallium binding by transferrin, and we have determined the macroscopic gallium binding
… transferrin. A unique feature of the transferrins is that metal bindingrequires the concomitant …

… to other subcellular macromolecules. Also, iron and … to gallium-transferrin in the blood, and
the gallium-transferrin … tracer amounts of iodinated mouse transferrin were added to these …

… of nonferrous metals as potential in vivo tracers of transferrin-based therapeutics J. Am. Soc.
… Gas-phase processes and measurements of macromolecular properties in solution: on the …

… Comparisons of iron-59, indium-l I1,and galliurn-68 transferrin asa macromolecular
tracer of vascular permeability and the transferrin receptor. J Nud Med 1989:30:1676—1685. …

… rapidly saturates binding and effectively abolishes concentration of tracer 67 Ga. Hegge et
al… with the observed uptake of gallium and iron. We found a macromolecular component of the …

… result in preferential retention of macromolecules via enhanced … routing are frequently
overlooked is transferrin (Tf), an 80 kDa … noncognate metals (indium and gallium), the interaction …

… of tracer 67Ga. In earlier work [37], it was shown that after IV administration, 67Ga, like 59Fe,
was incorporated into ferritin in rabbit liver. Some of these gallium-binding macromolecules …

… entry and residency time of macromolecules in the interstitial space … transferrin and [67Gajcitrate.
Since after iv injection of [67Ga]citrate 99% of the tracer is bound to plasma transferrin (8…