… the dissociation of more gallium from transferrin to restore the … compared to gallium-transferrin
drives the binding of gallium to … of gallium is probably linked to the increased permeability …

… Therefore, one might expect the blood-brain barrier permeability to the smaller molecule
of 68Ga-EDTA to be much higher than to 67Ga-transferrin, which is supported by our …

Gallium has a long history as a diagnostic and chemotherapeutic agent. The pharmacological
properties of Ga(III) rely on chemical mimicry; when Ga(III) is exogenously supplied to …

… association of gallium and iron with transferrin ánd since the binding of gallium to transferrin
has not … Increased capillary permeability stimulated by histamine vas found to increase the …

… Gallium-67, mainly in the form of transferrin-Ga-67 complex, … Transferrin is present in the
inflammatory lesions (50) due to leakage of plasma protein via increased vascular permeability…

… The handling of elemental gallium is not thought to be harmful, but this assumption does not
… The permeability of the pig and human skin is not directly compared in the current work due …

… gallium does not model Al well. The Kin for Al was reported for the free ion and in the
presence of transferrin (at an Al:transferrin … transferrin (holotransferrin) binds to the transferrin …

… The apparently low cerebral capillary permeability to 12'I-Tf may also be explained if the
molecule is being recycled back into plasma from the endothelium, using the normal en…

… tumor cell permeability is the principal cause of gallium citrate accumulation by said tumors
(48). … These results indicate that the transport of non-transferrin-bound gallium is an important …

The work presented in this thesis focus on the design of targeted nanosized and molecular
tools, for the design of gallium radiopharmaceuticals with potential application in cancer …