… Quantitative trait locus analysis in inbred strains of mice challenged with lithogenic diets …
with approximately 2000 gene-centric loci involved in lipid metabolism and obesity pathways. …

… genetic mechanisms of cholesterol gallstone disease in humans. Here, we summarize biliary
lipid physical chemistry and the molecular pathogenesis of cholesterol gallstone formation, …

… The instrument variables were first assessed to discern whether they were robustly associated
with their lipid traits by computing the proportion of variance explained and the F score …

… The differences between the inbred mouse strains in gallstone formation triggered
quantitative trait loci (QLT) analyses to locate chromosomal regions of interest containing genes …

… characteristic … fat intake (mostly saturated fats) and gallstones [Citation22]. Similarly a French
study showed a positive association between gallstone disease and total and saturated fat …

… We discuss the physical-chemical mechanisms of gallstone … of the pathogenesis of gallstone
formation and the potential … , lipid metabolism, and regulation of biliary lipid secretion in …

… Gallstone susceptibility is a ‘complex trait’ with genetic factors estimated to contribute 25%
of the risk [ 5 ] and environmental factors accounting for the remainder. Studies on both …

… Bile lipid analyses revealed cholesterol stones in five patients and pigment stones in one.
Bile lipid … The baseline characteristics of GD1 patients are notable for two metabolic …

… gallstones, based on composition. In this study, the association between these six gene SNPs
and gallstone disease … mutations among the three subtypes of gallstone were determined. …

… cholesterol vesicles which have characteristics of affinity aggregation. … Gallstones and
cardiovascular disease share common risk factors such as age, sex, obesity, and disorders of lipid …