… cell death in bystander cells. We detected apoptosis in bystander cells and found that bystander
cell death … determined that ganciclovir incubations for 10 h were sufficient to induce cell …

… pathways leading to cell death by suicide gene therapy in brain tumor cells. Despite a …
have yet investigated the pathways involved in CD/5-FC-induced cell death of tumor cells. …

… of cell death induced by ganciclovir treatment of tk gene-expressing C6 glioma cells were
investigated. We provide evidence that the cell cycle blockade triggered by ganciclovir occurs …

… VP22-TK chimeric protein between cells in sufficient quantities to induce Neuro 2A cell death
in response to GCV treatment, despite the absence of gap junctions in these cells, and thus …

… of a "suicide" gene into tumoral cells. The system can be used in vitro or in vivo to induce
tumor cell death. A plasmid carrying the herpes simplex virus thymidine kinase (HSV-TK) gene …

… of control cells upon exposure to GCV. Transfection of the procaspase-3ąexpressing cells
with … We also show that the increased tumor cell death is caused by caspase-3 activation and …

… Although DNA damage may be involved in the initiation of the cell death response (3), the
… in target cells after suicide gene therapy have not yet been defined. Apoptotic cell death is …

… (A) Reproductive cell death was determined by colony formation. Two independent experiments
in duplicates were performed. Fraction of survived colonies is expressed as percentage …

… )-induced cell death in constitutively resistant cells. These findings may be used to increase
the efficacy of TK/GCV and other suicide gene therapy systems for the treatment of cancer. …

… kinase (HSV-tk) gene transfer followed by ganciclovir (GCV) treatment has been … mode of
cell death after GCV treatment in three human oral squamous cell carcinoma (SCC) cell lines …