… of articular cartilage. The aim of this study was to investigate if chondrocytes from human
articular cartilage express gap junction proteins called connexins (Cxs). We show that …

… that articular chondrocytes in cartilage are physically connected with distant chondrocytes
… Additionally, Cx43 protein is overexpressed in cartilage and synovial tissue of patients with …

… gap junctions in chondrocytes isolated from mature cartilage. These gap junctions are
composed of Cx43, a gap junction-specific protein, which was originally identified in rat heart(”) …

… We have recently shown that human articular chondrocytes express integral membrane
proteins known as connexins (Cxs).10 Cxs form hemichannels that in turn form gap junctions (…

… group have revealed that primary human chondrocytes in tissue and in … gap junction (GJ)
channels. These results challenge the existing thesis of cartilage physiology, that chondrocytes …

… 3 gap junction genes, GJA1 (Cx43), GJC1 (Cx45), and Panx1, in both human primary costal
and articular cartilage… the primary cilium of bovine chondrocytes and involved in ATP release …

… However, contrasting results in separate studies in healthy human articular cartilage 75
and in rodents 77 revealed that Cx43 was expressed primarily in the superficial zone of the …

… that an artefact of fixation explains our inability to verify the presence of full gap junctions.
Alternatively, gap junctions may not need to form completely to be functional: hemichannels (Li …

… gap junctions in mature articular chondrocytes may have important consequences for cartilage
function: in a tissue lacking extensive vascularization, metabolic coordination among the …

… , which probably occur between most cell types including tendon cells, 24 chondrocytes,
25 osteoblasts, 29 meniscus cells, 12 and synovial lining cells, 16 has led to the idea that …