… explains for the compromised development of the tissues … bone tissue comprising of intact
gap junctions has limited our understanding of the significance of GJIC in the process of bone …

… have elucidated some of the roles of gap junctions in bone development and maintenance.
… will discuss the role of gap junctions in skeletal and limb development. Bone is formed by two …

… These findings suggest that functional hemichannels cannot compensate for the absence
of gap junctions during bone development. However, the role of hemichannels for bone …

… that gap junctional intercellular communication (GJIC) contributes to mechanotransduction
in bone and, in so doing, contributes to the regulation of bone … We propose that gap junctions …

… Gap junctions and Cx43 play essential roles in osteoblast differentiation and bone
development in human and animal models in vivo (reviewed by Stains and Civitelli (37)). Cx43 …

… members of the connexin family of gap junction proteins (connexin42, Cx42; connexin43,
Cx43; and connexin45, Cx45) was evaluated during bone formation in the mandibular process …

… bone. Polarized-light microscopy showed maintenance of this pattern at six, eight, and twelve
weeks, even when the defect was filled with lamellar bone. … Intercellular gap junctions are …

… immunolocalised in sections of developing bone (Parker et al… bone junction, we would
expect that gap junctions also link the marrow stromal cells and preosteoblasts during active bone …

… Cx43 gap junctions and hemichannels regulate cell signaling pathways, gene expression,
mechanotransduction and cell survival in bone … is critical to the development of treatments that …

… Findings in the cherubism mouse model suggest that removal of TNF-α prevents development
of the bone phenotype. ► We treated two children with active cherubism with the TNF-α …