Connexins and gap junctions in the EDHF phenomenon and conducted vasomotor responses

C De Wit, TM Griffith - Pflügers Archiv-European Journal of Physiology, 2010 - Springer
… By contrast, in arteries where the EDHF phenomenon depends on gap junctions, electrotonic
spread of endothelial hyperpolarization would be expected to close BK Ca channels, both …

Endothelium‐dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis?

TM Griffith - British journal of pharmacology, 2004 - Wiley Online Library
… An alternative explanation for the EDHF phenomenon is that direct intercellular communication
via gap junctions allows passive spread of agonist-induced endothelial hyperpolarization …

Gap junction-dependent increases in smooth muscle cAMP underpin the EDHF phenomenon in rabbit arteries

HJ Taylor, AT Chaytor, DH Edwards… - … and biophysical research …, 2001 - Elsevier
… ATPase (20), (ii) enhanced electrical and chemical signaling via gap junctions (21, 22), and
(… By exploiting the dependence of EDHF-type responses on gap junctional communication it …

cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions

TM Griffith, AT Chaytor, HJ Taylor… - Proceedings of the …, 2002 - National Acad Sciences
… To further delineate the roles of myoendothelial and smooth muscle gap junctions in the
EDHF phenomenon, we investigated the effects of ACh on smooth muscle membrane potential …

Connexin‐mimetic peptides dissociate electrotonic EDHF‐type signalling via myoendothelial and smooth muscle gap junctions in the rabbit iliac artery

AT Chaytor, LM Bakker, DH Edwards… - British journal of …, 2005 - Wiley Online Library
… the EDHF phenomenon is electrotonic in nature, and highlight the contribution of myoendothelial
and homocellular smooth muscle communication via gap junctions to arterial function. …

Role of gap junctions in the responses to EDHF in rat and guinea‐pig small arteries

G Edwards, M Feletou, MJ Gardener… - British journal of …, 1999 - Wiley Online Library
… In some preparations, such as the rat hepatic and mesenteric arteries, gap junctions play
some role in the EDHF response. This phenomenon is nevertheless predominantly due to a …

[HTML][HTML] EDHF–are there gaps in the pathway?

G Edwards, AH Weston - The Journal of Physiology, 2001 - ncbi.nlm.nih.gov
… They conclude that gap junctions play a key role in the EDHF … the lack of a selective gap
junction inhibitor and their study highlights … Study of the EDHF phenomenon has brought sharp …

EDHF: bringing the concepts together

R Busse, G Edwards, M Félétou, I Fleming… - Trends in …, 2002 - cell.com
… three explanations for the EDHF phenomenon: (1) the … EDHF-mediated responses; (2)
endothelial cell hyperpolarization is transmitted to the vascular smooth muscle via gap junctions; …

Increases in endothelial Ca2+ activate KCa channels and elicit EDHF-type arteriolar dilation via gap junctions

Z Ungvari, A Csiszar, A Koller - American Journal of …, 2002 - journals.physiology.org
… Recent studies also demonstrated inhibition of ACh-induced, EDHF-type … gap junction
inhibitors. To provide further evidence for primary role for gap junctions in mediation of EDHF-type …

Factors, fiction and endothelium‐derived hyperpolarizing factor

SL Sandow - Clinical and Experimental Pharmacology and …, 2004 - Wiley Online Library
gap junctions in the EDH(F) phenomenon. More extensive reviews on endothelium-derived
hyperpolarizing factor (EDHFEDHF may be redundant, because the EDHF phenomenon can …