[HTML][HTML] Human articular chondrocytes express multiple gap junction proteins: differential expression of connexins in normal and osteoarthritic cartilage

MD Mayan, P Carpintero-Fernandez… - The American journal of …, 2013 - Elsevier
junction proteins called connexins (Cxs). We show that human chondrocytes in tissue express
… We also find that primary chondrocytes from adults retain the capacity to form functional …

[HTML][HTML] Intercellular communication via gap junction channels between chondrocytes and bone cells

P Carpintero-Fernandez, R Gago-Fuentes… - … et Biophysica Acta (BBA …, 2018 - Elsevier
… BCs and SCs, and to determine the extent of gap junction mediated coupling, we performed
experiments on cell pairs to record junctional currents by dual whole-cell voltage clamp. Fig. …

Articular chondrocyte network mediated by gap junctions: role in metabolic cartilage homeostasis

MD Mayan, R Gago-Fuentes… - Annals of the …, 2015 - ard.bmj.com
… methods.20 ,21 Primary human chondrocytes were placed on an inverted microscope for …
of a monolayer of primary chondrocytes obtained from human adults, as previously reported.…

[HTML][HTML] … gap junctions and Cx43 expression in immortalized human chondrocyte cell line: a potential model in the study of cell communication in human chondrocytes

R Gago-Fuentes, P Carpintero-Fernandez… - Osteoarthritis and …, 2014 - Elsevier
… group have revealed that primary human chondrocytes in tissue and in … gap junction (GJ)
channels. These results challenge the existing thesis of cartilage physiology, that chondrocytes

Chondrocytes isolated from mature articular cartilage retain the capacity to form functional gap junctions

HJ Donahue, F Guilak, MA Vander Molen… - Journal of bone and …, 1995 - academic.oup.com
gap junctions in chondrocytes isolated from mature cartilage. These gap junctions are
composed of Cx43, a gap junction-… , chondrocytes isolated from mature cartilage express a gap

Joint diseases: from connexins to gap junctions

HJ Donahue, RW Qu, DC Genetos - Nature Reviews Rheumatology, 2018 - nature.com
… Cx43 localizes to the margin of cells and is expressed in 80–100% of chondrocytes in
each zone; it forms gap junctions when a lacuna contains multiple chondrocytes 76 (Fig. 3). …

[HTML][HTML] Functional roles of connexins and gap junctions in osteo-chondral cellular components

A Zappalà, IR Romano, F D'Angeli… - International Journal of …, 2023 - mdpi.com
… in the mouse and human genomes [6,7]. Gap junctions consent intercellular transfer of small
… The importance of Cx43 for chondrocyte differentiation was underlined by results obtained …

[HTML][HTML] Gap junctions in skeletal development and function

JP Stains, R Civitelli - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2005 - Elsevier
… are required for the differentiation of chondrocytes, as inhibition of gap junctional communication
with 18α-glycyrrhetinic acid reduces production of proteoglycans and type II collagen. …

Connexins and pannexins in the skeleton: gap junctions, hemichannels and more

LI Plotkin, JP Stains - Cellular and molecular life sciences, 2015 - Springer
chondrocytes. Donahue and colleagues reported the expression of Cx43 and the presence
of functional gap junction channels in chondrocytes … of Cx43, human chondrocytes express …

TGF‐β1 promotes gap junctions formation in chondrocytes via Smad3/Smad4 signalling

Q Wang, C Zhou, X Li, L Cai, J Zou, D Zhang… - Cell …, 2019 - Wiley Online Library
… in chondrocytes needs to be … and gap junctions in chondrocytes. To investigate the effect
of TGF-β1 on cell-cell communication, changes in cell migration and proliferation, gap junction