Gap junctions and the regulation of cellular functions of stem cells during development and differentiation

JE Trosko, CC Chang, MR Wilson, B Upham… - Methods, 2000 - Elsevier
… As a stimulus for our research into the role of stem cells in carcinogenesis, we needed to
isolate human stem cells to test the hypothesis that stem cells are the target cells for …

Role of gap junctions in embryonic and somatic stem cells

RCB Wong, MF Pera, A Pébay - Stem cell reviews, 2008 - Springer
… events in many stem cells, including cell proliferation, differentiation … gap junctions in both
embryonic and somatic stem cells, as well as their potential role in growth control and cellular

Presence of functional gap junctions in human embryonic stem cells

RCB Wong, A Pébay, LTV Nguyen, KLL Koh… - Stem …, 2004 - academic.oup.com
cell differentiation, and cell apoptosis. This study aimed to determine the presence and
functionality of gap junctions in human embryonic stem cells … ES cells express two gap junction

Gap junctions and connexon hemichannels in human embryonic stem cells

JE Huettner, A Lu, Y Qu, Y Wu, M Kim… - Stem Cells, 2006 - academic.oup.com
cells of the inner cell mass and surrounding trophectoderm. Here we demonstrate … gap
junctional communication between human embryonic stem (ES) cells, the pluripotent cells

Human mesenchymal stem cells make cardiac connexins and form functional gap junctions

V Valiunas, S Doronin, L Valiuniene… - The Journal of …, 2004 - Wiley Online Library
… In this study we demonstrate that hMSC connexins, the building block proteins of gap
junctions, can form functional gap junctions with one another, with cell lines expressing cardiac …

[PDF][PDF] The role of stem cells and gap junctional intercellular communication in carcinogenesis

JE Trosko - BMB Reports, 2003 - researchgate.net
… the “stem cell theory of carcinogenesis” and “the gap junctionalstem cells and the
demonstration that these adult stem cells … , the target cells for carcinogenesis are the adult stem

The role of stem cells and gap junctions as targets for cancer chemoprevention and chemotherapy

JE Trosko - Biomedicine & pharmacotherapy, 2005 - Elsevier
… " cells will require different agents. A hypothesis will be proposed that … stem cells, which
lack gap junctional intercellular communication (GJIC-) or their early progenitor daughter cells, …

Communication via gap junctions underlies early functional and beneficial interactions between grafted neural stem cells and the host

J Jäderstad, LM Jäderstad, J Li… - Proceedings of the …, 2010 - National Acad Sciences
… The number of neural stem cells (NSCs), for example, that differentiate into … cellcell coupling
via gap junctions that modulate network activity. When we observed that such gap junction

[HTML][HTML] Epidermal stem cells do not communicate through gap junctions

M Matic, WH Evans, PR Brink, M Simon - Journal of investigative …, 2002 - Elsevier
… in corneal stem cells. Accordingly, we investigated whether connexin 43, a gap junction protein
… human epidermis, can serve as a negative marker for keratinocyte stem cells. In humans, …

Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and …

JY Hahn, HJ Cho, HJ Kang, TS Kim, MH Kim… - Journal of the American …, 2008 - jacc.org
cell-to-cell communication through gap junctions and that treatment with GFs might potentiate
gap junction-… Recent data support the hypothesis that gap junction might propagate cell