Clinical significance of the expression of DNA methyltransferase proteins in gastric cancer

J Yang, X Wei, Q Wu, Z Xu, D Gu… - Molecular …, 2011 - spandidos-publications.com
… Although overexpression of DNMTs is not equal to the aberrant DNA methylation pattern in
gastric cancer, our findings, such as the distribution of DNMTs and the correlations between …

The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer

WJ Ding, JY Fang, XY Chen, YS Peng - Digestive diseases and sciences, 2008 - Springer
… of DNA methyltransferase (DNMT) proteins in gastric cancer (GC… expression of the 3 DNMTs
in gastric tissues. We discovered that … Therefore, DNMT overexpression is involved in gastric

MiR-148a regulates MEG3 in gastric cancer by targeting DNA methyltransferase 1

J Yan, X Guo, J Xia, T Shan, C Gu, Z Liang, W Zhao… - Medical oncology, 2014 - Springer
… MiR-148a can suppress gastric tumorigenesis through regulating the expression of … as
DNA methyltransferase 1(DNMT-1). We examined the expression of MEG3 in 52 gastric cancer

DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer

K Mutze, R Langer, F Schumacher, K Becker… - … journal of cancer, 2011 - Elsevier
… may influence the effect of DNA-damaging drugs. We examined the prognostic and predictive
impact of DNA methyltransferase (DNMT) 1 and 3b expression in gastric carcinomas (GC) …

DNA methyltransferases and gastric cancer: insight into targeted therapy

S Fattahi, M Golpour, F Amjadi-Moheb… - …, 2018 - Taylor & Francis
… by DNA methyltransferases (DNMTs) are a well-characterized epigenetic hallmark in gastric
cancer. The reversible nature of epigenetic alterations and central role of DNA methylation …

… DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG …

T Etoh, Y Kanai, S Ushijima, T Nakagawa… - The American journal of …, 2004 - Elsevier
gastric and colorectal cancers. However, most previous analyses concerning DNMT1 expression
in human cancers … To our knowledge, DNMT1 protein expression in gastric cancers has …

Accumulation of DNA methylation is associated with tumor stage in gastric cancer

N Oue, Y Mitani, J Motoshita… - Cancer …, 2006 - Wiley Online Library
… The authors purpose in this study was to clarify the difference in terms of clinicopathologic
features between gastric cancer (GC) with high numbers of DNA methylated genes and CpG …

MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer

A Zhu, J Xia, J Zuo, S Jin, H Zhou, L Yao, H Huang… - Medical oncology, 2012 - Springer
… -148a is inactivated by DNA hypermethylation of promoter region in gastric cancer, which is
… in gastric cancer, and this may in turn result in over-expression of DNMT1 and promote DNA

Risk-association of DNA methyltransferases polymorphisms with gastric cancer in the Southern Chinese population

XX Yang, XQ He, FX Li, YS Wu, Y Gao, M Li - International journal of …, 2012 - mdpi.com
DNA hypomethylation and/or hypermethylation are presumed to be early … more DNA
methyltransferases (DNMTs) have been suggested to play roles in carcinogenesis of gastric cancer (…

Antitumor Effect of Simvastatin in Combination With DNA Methyltransferase Inhibitor on Gastric Cancer via GSDME-Mediated Pyroptosis

Y Xia, Y Jin, D Cui, X Wu, C Song, W Jin… - Frontiers in …, 2022 - frontiersin.org
… due to promoter hypermethylation is associated with gastric cancer (GC), which is
confirmed … (DOX)- inducible Tet-on system or DNA methyltransferase inhibitor 5-Aza-2′-deoxycytidine …