… of the hMLH1 promoter is related to increasing age and gastric carcinogenesis, we
examined hMLH1 methylation and expression in 100 gastric cancers. hMLH1 methylation and …

… mechanism underlies hMLH1 gene inactivation and MMR deficiency. Therefore, we studied
the prevalence of hMLH1 promoter hypermethylation in a total of 65 gastric tumors: 18 with …

… the hMLH1 promoter in causing MSI-H in sporadic gastric cancer. Aberrant hMLH1 promoter
… This is associated with a lowered level of mRNA and a total absence of the hMLH1 protein …

… not associated with gastric cancer with hypermethylation of the hMLH1 promoter, although
… increased likelihood of gastric cancer without hypermethylation of the hMLH1 promoter, and …

… of the hMLH1 promoter region in MSI + gastric tumors and … promoter, accounting for, in
the present study, 100% of cases … that hMLH1 promoter hypermethylation in gastric tumors …

… We found that the hMLH1 promoter was methylated in the cancer DNA from 4 cases (G2,
G13, G15 and G24), which displayed aberrant hMLH1-protein expression (Fig. 2). In patient …

… promoter methylation and tumor stage (p = 0.028) and location (p = 0.025). The rate of
hMLH1 promoter … , showing the importance of the other mechanisms, in gastric tumorigenesis. …

… of the hMLH1 gene promoter in 17 solitary gastric cancers (… ), and 13 multiple gastric cancers
(eight microsatellite instability-… also examined non-cancerous gastric mucosa both adjacent …

… hMLH1 hypermethylation, hMLH1 expression and MSI in a group of early gastric cancers
and gastric … In addition, we found that 6/8 low-frequency MSI (MSI-L) gastric cancers at …

… of hMLH1 promoter methylation in gastric cancers, but we could not provide a good solution
about sources of heterogeneity; Also, there may be differential effects in hMLH1 methylation …