… TNF-α Tumor necrosis factor α (TNF-α) belongs to a family of structurally related ligands that
… Almost all members of the TNF familiy exert their effects as transmembrane proteins through …

… that specifically target tumor necrosis factor (TNF)α, our therapeutic approach to inflammatory
diseases has dramatically changed. There are currently three anti-TNFα drugs available: …

… These pathways are involved in innate immune responses that include cytokines such as
tumor necrosis factor (TNF)-α, IL-1, IL-18, the chemotactic peptide fMet-Leu-Phe, and a newly …

… TNF-α interaction with its receptors. Further research on the effects of TNF-α in gastrointestinal
(GI) diseases… the discovery of TNF-α has had on the treatment of GI diseases such as IBD. …

… The acute disease occurs shortly after transplantation and consists of inflammatory lesions
affecting the skin, liver and gastrointestinal tract. The delayed type occurs greater than 90 …

… cytokines interleukin-6, tumor-necrosis-factor-α and interleukin-1β, … gastrointestinal diseases
such as Crohn's disease and acute pancreatitis, its levels correlate well with clinical disease …

… , urea and creatinine, IL-1 and TNF-α than wildtype mice, and also showed reduced …
Serum levels of TNF-α mirror the changes seen in TLR4 expression, indicating that systemic …

… explores the possible underlying mechanisms linking obesity to gastrointestinal diseases. It
also looks at the role of mesenteric fat in determining severity and course of Crohn's disease. …

… TNF-α and IL-8 were independent of NOD2 status. By contrast, ileal levels of Paneth cell
α-defensins from patients with Crohn's disease … and disease progression of Crohn's disease is …

… TNFα might rather act destructively in regard to inflammation and barrier integrity and therefore
anti-TNFα treatment in this disease … diarrhoea and gastrointestinal disease worldwide …