… NK3 receptors. … receptor antagonists for control of intestinal motility and consequent potential
usefulness in diseases characterized by disturbances of intestinal transit and (or) intestinal …

… normal GI functions and that these receptors can modulate visceral sensitivity are good
starting points for testing this class of drugs in GI diseases characterised by altered GI motility. …

… that tachykinin receptors, which in the digestive system are … attractive targets for novel
therapeutics in gastroenterology. … Tachykinins can both stimulate and inhibit GI motility, the net …

… gastrointestinal tract, tachykinins are peptide neurotransmitters in nerve circuits that regulate
intestinal motility… of tachykinin receptors, or by peptide analog with tachykinin …

… The result of these integrated responses is that TKs can stimulate and inhibit gastrointestinal
motility, the net effect depending on the site and the receptor. These motor actions are …

… modulators of intestinal motility in animal species studied so far, including humans. Modulation
of … NK2 receptors can have functional consequences on human intestinal motility and …

… may also stimulate the release of tachykinins … receptors are more sensitive to cholecystokinin
… blockade of VIP receptors with a selective VIP receptor antagonist or neutralization …

… In the stomach all three known tachykinin receptors seem to … Localization of receptors
Localization of tachykinin receptors in the stomach has been visualized using three methods: …

… the involvement of tachykinin type 2 receptors (NK2r) in the regulation of human colonic
motility, few … Some of NK2r-expressing neurons and nerves were tachykinin-IR. No NK2r-IR was …

… suggested a role for antagonism of NK 2 receptors in modulation of GI chemical‐induced
altered motility and of stress‐induced altered bowel habits. Clinical studies and in particular a …