Gefitinib or Erlotinib vs Chemotherapy for EGFR Mutation-Positive Lung Cancer: Individual Patient Data Meta-Analysis of Overall Survival

CK Lee, L Davies, YL Wu, T Mitsudomi… - JNCI: Journal of the …, 2017 - academic.oup.com
… This question cannot be addressed in this meta-analysis of gefitinib and erlotinib as most of
… relative PFS benefit, OS did not statistically significantly differ between gefitinib or erlotinib vs …

Erlotinib after gefitinib failure in relapsed non-small cell lung cancer: clinical benefit with optimal patient selection

A Hata, N Katakami, H Yoshioka, S Fujita, K Kunimasa… - Lung cancer, 2011 - Elsevier
Iressa Survival Evaluation in Lung Cancer (ISEL) study, gefitinib failed to show a survival
benefit … Conversely, erlotinib demonstrated a survival benefit for recurrent advanced NSCLC in …

[HTML][HTML] Use of the epidermal growth factor receptor inhibitors gefitinib and erlotinib in the treatment of non-small cell lung cancer: a systematic review

R Feld, SS Sridhar, FA Shepherd, JA Mackay… - Journal of Thoracic …, 2006 - Elsevier
… statistically significant survival benefit for erlotinib therapy as … gefitinib as second-line or
subsequent therapy; however, a statistically significant survival benefit was not found for gefitinib

Survival benefits from afatinib compared with gefitinib and erlotinib among patients with common EGFR mutation in first‐line setting

WC Kwok, JCM Ho, TCC Tam, MSM Ip… - Thoracic …, 2022 - Wiley Online Library
… afatinib followed by osimertinib could have survival benefit for patients with EGFR mutated
… by osimertinib in terms of survival benefit over gefitinib or erlotinib, which was not reported in …

… survival benefit from gefitinib in patients with advanced lung adenocarcinoma: a historical comparison of patients treated before and after gefitinib approval in Japan

T Takano, T Fukui, Y Ohe, K Tsuta… - Journal of Clinical …, 2008 - ascopubs.org
… Eight large-scale, randomized, phase III trials were conducted to evaluate the survival benefits
of gefitinib or erlotinib (Tarceva; OSI Pharmaceuticals Inc, Melville, NY), another EGFR-TKI…

[HTML][HTML] Impact on disease-free survival of adjuvant erlotinib or gefitinib in patients with resected lung adenocarcinomas that harbor EGFR mutations

YY Janjigian, BJ Park, MF Zakowski, M Ladanyi… - Journal of Thoracic …, 2011 - Elsevier
… with adjuvant cisplatin chemotherapy has no survival benefit. … of a clinical trial of perioperative
gefitinib. The surgical database … erlotinib or gefitinib delivery, disease status, and survival. …

Gefitinib or erlotinib as maintenance therapy in patients with advanced stage non-small cell lung cancer: a systematic review

X Chen, Y Liu, OD Røe, Y Qian, R Guo, L Zhu, Y Yin… - PloS one, 2013 - journals.plos.org
… The PFS benefit was consistent in all subgroups including stage, sex, ethnicity, performance
… had more pronounced PFS benefit. Overall survival benefit was observed in patients with …

[HTML][HTML] Survival benefit with erlotinib maintenance therapy in patients with advanced non-small-cell lung cancer (NSCLC) according to response to first-line …

B Coudert, T Ciuleanu, K Park, YL Wu, G Giaccone… - Annals of oncology, 2012 - Elsevier
… inhibitor (EGFR TKI) erlotinib is an established option for … Treatment with erlotinib produces
significant survival benefits … These benefits are particularly important, given that survival

[HTML][HTML] Risk of treatment-related toxicities from EGFR tyrosine kinase inhibitors: a meta-analysis of clinical trials of gefitinib, erlotinib, and afatinib in advanced EGFR …

PN Ding, SJ Lord, V Gebski, M Links, V Bray… - Journal of Thoracic …, 2017 - Elsevier
… A systematic review of lung cancer patients’ preferences found that even small survival
benefits are sufficient to justify chemotherapy for advanced or metastatic NSCLC, 6 but patients’ …

Comparison of gefitinib and erlotinib in advanced NSCLC and the effect of EGFR mutations

JY Wu, SG Wu, CH Yang, YL Chang, YC Chang… - Lung cancer, 2011 - Elsevier
… Preplanned sub-group analyses showed significantly longer survival in the gefitinib group
… Among patients of Asian origin, treatment with gefitinib showed a survival advantage than …