Use of the epidermal growth factor receptor inhibitors gefitinib, erlotinib, afatinib, dacomitinib, and icotinib in the treatment of non-small-cell lung cancer: a systematic …

PM Ellis, N Coakley, R Feld, S Kuruvilla, YC Ung - Current oncology, 2015 - mdpi.com
gefitinib, erlotinib, afatinib, dacomitinib, or icotinib had a higher probability of experiencing
an event; conversely, a hr less than 1.0 suggests that patients receiving erlotinib or gefitinib

[HTML][HTML] Comparison of effectiveness and adverse effects of gefitinib, erlotinib and icotinib among patients with non‑small cell lung cancer: A network meta‑analysis

Y Liu, Y Zhang, G Feng, Q Niu… - Experimental and …, 2017 - spandidos-publications.com
… compared with gefitinib and icotinib (P<0.05). In conclusion, gefitinib, erlotinib and icotinib
had … However, gefitinib resulted in a lower frequency of fatigue, and nausea and vomiting, …

[HTML][HTML] Comparison of first-generation EGFR-TKIs (gefitinib, erlotinib, and icotinib) as adjuvant therapy in resected NSCLC patients with sensitive EGFR mutations

Q He, J Liu, X Cai, M He, C Li, H Liang… - Translational Lung …, 2021 - ncbi.nlm.nih.gov
gefitinib vs. chemotherapy in EGFR-mutant patients with completely resected NSCLC confirmed
that adjuvant gefitinib … EGFR-TKIs included icotinib, erlotinib and gefitinib. Previous trial …

[HTML][HTML] Network meta-analysis of erlotinib, gefitinib, afatinib and icotinib in patients with advanced non-small-cell lung cancer harboring EGFR mutations

W Liang, X Wu, W Fang, Y Zhao, Y Yang, Z Hu, C Xue… - PloS one, 2014 - journals.plos.org
… indicated that erlotinib, gefitinib, afatinib and icotinib shared … Erlotinib and afatinib revealed
potentially better efficacy but significant higher toxicities compared with gefitinib and icotinib

[HTML][HTML] Tyrosine kinase inhibitors show different anti-brain metastases efficacy in NSCLC: a direct comparative analysis of icotinib, gefitinib, and erlotinib in a nude …

J Tan, M Li, W Zhong, C Hu, Q Gu, Y Xie - Oncotarget, 2017 - ncbi.nlm.nih.gov
… , we found that gefitinib penetrated the blood-… erlotinib or icotinib in a nude mouse model.
The 1-h ratio of brain metastases to plasma concentration for gefitinib, erlotinib, and icotinib

Simultaneous quantitative detection of afatinib, erlotinib, gefitinib, icotinib, osimertinib and their metabolites in plasma samples of patients with non-small cell lung …

X Xiong, Y Zhang, Z Wang, C Zhou, P Yang, X Du… - Clinica Chimica …, 2022 - Elsevier
… A new method for the simultaneous analysis of five EGFR-TKIs (afatinib, erlotinib, gefitinib,
icotinib and osimertinib) and their metabolites in human plasma samples was developed and …

Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial

Y Shi, L Zhang, X Liu, C Zhou, S Zhang, D Wang… - The lancet …, 2013 - thelancet.com
Gefitinib and erlotinib are EGFR TKIs that were shown to greatly improve clinical outcomes
and safety when compared with chemotherapy or placebo in second-line or further-line …

Icotinib, a selective EGF receptor tyrosine kinase inhibitor, for the treatment of non-small-cell lung cancer

F Tan, Y Shi, Y Wang, L Ding, X Yuan, Y Sun - Future Oncology, 2015 - Taylor & Francis
… (ICOGEN), which showed icotinib is noninferior to gefitinib. This review will discuss the role
of … In this study, the quality-adjusted life years (QALYs) for icotinib, gefitinib and erlotinib were …

Efficacy of icotinib and gefitinib in advanced lung adenocarcinoma with EGFR mutation

H CUI, J GUAN, G LIAO, P LIU… - … OF CHINESE PLA …, 2015 - xuebao.301hospital.com.cn
icotinib group and gefitinib group randomly, and patients in icotinib group were treated
with icotinib three times a day by 125 mg, patients in gefitinib group were treated with gefitinib

[HTML][HTML] Icotinib is as efficacious as gefitinib for brain metastasis of EGFR mutated non-small-cell lung cancer

K Liu, G Jiang, A Zhang, Z Li, J Jia - BMC cancer, 2020 - Springer
icotinib arm and 2 in the gefitinib arm. These results indicated that icotinib was as efficacious
as gefitinib … is cheaper than any other targeted agents such as gefitinib, erlotinib and afatinib…