… in persons with lung cancer. Many of the principles of management relevant to gefitinib are
distinct … practical guidelines on the use of gefitinib in patients with non–small-cell lung cancer. …

… This review discusses the use of gefitinib in Asian patients with advanced NSCLC using
the extensive clinical data available and also summarizes data on the discovery of the EGFR …

… and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst. 2005; 97: 643-655 …
patients with non-small-cell lung cancer receiving gefitinib in a randomized controlled trial. …

… described in patients with non–small-cell lung cancer (… gefitinib. One of these mutations,
L858R (Leu→Arg), is also found in NSCLC cell line H3255, which is very sensitive to gefitinib …

… chemotherapy in patients with locally advanced non-small cell lung carcinoma. Cancer 2001;
… in previously treated non-small cell lung cancer patients. Semin Oncol 2003; 30:30-38. 6. …

… in patients with basal Akt activation. Lung cancer is the leading cause of cancer death …
intervention, the prognosis of patients with non–small-cell lung cancer (NSCLC) remains poor, …

… We randomly assigned 230 patients with metastatic, non–small-cell lung cancer and EGFR
mutations who had not previously received chemotherapy to receive gefitinib or carboplatin–…

ContextMore persons in the United States die from non–small cell lung cancer (NSCLC) than
from breast, colorectal, and prostate cancer combined. In preclinical testing, oral gefitinib …

… Seventy patients with relapsed non–small cell lung carcinoma were enrolled in the …
more patients were treated with gefitinib. Response evaluations were feasible in 80 patients…

Background: Brain metastases are a common occurrence in patients with non-small-cell
lung cancer (NSCLC). Whole-brain radiotherapy (WBRT) is the standard therapy; more …