Clinical course of patients with non–small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib

GJ Riely, W Pao, DK Pham, AR Li, N Rizvi… - Clinical cancer …, 2006 - AACR
… EGFR mutations with clinical factors predictive of response to erlotinib or gefitinib, we found
that … with patients with EGFR L858R after treatment with erlotinib or gefitinib (P = 0.01). …

[HTML][HTML] Distinct clinical course of EGFR-mutant resected lung cancers: results of testing of 1118 surgical specimens and effects of adjuvant gefitinib and erlotinib

SP D'Angelo, YY Janjigian, N Ahye, GJ Riely… - Journal of Thoracic …, 2012 - Elsevier
… of adjuvant erlotinib or gefitinib delivery were recorded. Patients at MSKCC receive adjuvant
erlotinib or gefitinib by enrolling in phase 2 clinical trials, 24 , 25 or outside of a clinical trial. …

Disease Flare after Tyrosine Kinase Inhibitor Discontinuation in Patients with EGFR-Mutant Lung Cancer and Acquired Resistance to Erlotinib or Gefitinib …

JE Chaft, GR Oxnard, CS Sima, MG Kris, VA Miller… - Clinical cancer …, 2011 - AACR
… and acquired clinical resistance to gefitinib and/or erlotinibclinical trials, we evaluated the
disease course and associated clinical and molecular factors of patients enrolled on clinical

[HTML][HTML] Risk of treatment-related toxicities from EGFR tyrosine kinase inhibitors: a meta-analysis of clinical trials of gefitinib, erlotinib, and afatinib in advanced EGFR …

PN Ding, SJ Lord, V Gebski, M Links, V Bray… - Journal of Thoracic …, 2017 - Elsevier
… We developed a clinical significance curve and risk-benefit contour to illustrate how the …
-Lung 7 to estimate the additional clinical benefit of afatinib versus gefitinib 5 and the results of …

The Impact of Initial Gefitinib or Erlotinib versus Chemotherapy on Central Nervous System Progression in Advanced Non–Small Cell Lung Cancer with EGFR …

S Heon, BY Yeap, NI Lindeman, VA Joshi… - Clinical Cancer …, 2012 - AACR
gefitinib or erlotinib significantly lowers the risk of CNS progression during the disease course
… Therefore, we retrieved information on the clinical presentation and course of our patients …

… of Central Nervous System Metastases in Patients with Advanced Non–Small Cell Lung Cancer and Somatic EGFR Mutations Treated with Gefitinib or Erlotinib

S Heon, BY Yeap, GJ Britt, DB Costa, MS Rabin… - Clinical cancer …, 2010 - AACR
… kinase inhibitors, gefitinib and erlotinib, on … clinical presentation and course of our patients
with advanced NSCLC and somatic EGFR mutations initially treated with gefitinib or erlotinib

Prospective assessment of discontinuation and reinitiation of erlotinib or gefitinib in patients with acquired resistance to erlotinib or gefitinib followed by the addition of …

GJ Riely, MG Kris, B Zhao, T Akhurst, DT Milton… - Clinical cancer …, 2007 - AACR
… progression of disease after discontinuation of erlotinib or gefitinib in patients … resistance to
erlotinib or gefitinib, continued treatment with erlotinib or … Clinical course of individual patients …

Effects of Erlotinib in EGFR Mutated Non-Small Cell Lung Cancers with Resistance to Gefitinib

DB Costa, KSH Nguyen, BC Cho, LV Sequist… - Clinical cancer …, 2008 - AACR
clinical course of 18 EGFR mutated NSCLC that were treated with gefitinib and, on resistance,
erlotinib… exon 19 deletions), and initial response to gefitinib 250 mg/d were consistent with …

Erlotinib after gefitinib failure in relapsed non-small cell lung cancer: clinical benefit with optimal patient selection

A Hata, N Katakami, H Yoshioka, S Fujita, K Kunimasa… - Lung cancer, 2011 - Elsevier
… the clinical course of patients with the longest three PFS (13.8, 12.4, and 11.6 months), gefitinib
was directly switched to erlotinib … In the clinical course of treatment with EGFR-TKIs, CNS …

Effectiveness of erlotinib in advanced non-small cell lung cancer in cases of gefitinib resistance after treatment of more than 6 months

H Saito, S Murakami, T Kondo, F Oshita… - Oncology Research …, 2012 - karger.com
… The best overall tumor responses (complete response (CR), partial response (CR), stable
disease (SD), progressive disease (PD)) during the course of different treatment modalities …