Gefitinib or Erlotinib vs Chemotherapy for EGFR Mutation-Positive Lung Cancer: Individual Patient Data Meta-Analysis of Overall Survival

CK Lee, L Davies, YL Wu, T Mitsudomi… - JNCI: Journal of the …, 2017 - academic.oup.com
… We assumed that gefitinib and erlotinib in the experimental … in this meta-analysis of gefitinib
and erlotinib as most of the … significantly differ between gefitinib or erlotinib vs chemotherapy …

Comparison of gefitinib and erlotinib in advanced NSCLC and the effect of EGFR mutations

JY Wu, SG Wu, CH Yang, YL Chang, YC Chang… - Lung cancer, 2011 - Elsevier
Overall survival after start of TK inhibitors in patients … overall survival both in univariate
analysis and in multivariate analysis. Gefitinib and erlotinib did not lead to different overall survival

The impact on overall survival (OS) of first-line gefitinib (G) and erlotinib (E) and of clinical factors in advanced non-small cell lung cancer (NSCLC) with activating …

C Lee, LC Davies, YL Wu, T Mitsudomi, A Inoue… - 2015 - ascopubs.org
8072 Background: We performed an individual pts data meta-analysis using trials that
compared G or E vs platinum doublet chemotherapy (CT) on OS outcome. Methods: Treatment-…

[HTML][HTML] Final overall survival results from a randomised, phase III study of erlotinib versus chemotherapy as first-line treatment of EGFR mutation-positive advanced …

C Zhou, YL Wu, G Chen, J Feng, XQ Liu, C Wang… - Annals of …, 2015 - Elsevier
… -line erlotinib or gefitinib in EGFR mutation-positive advanced NSCLC and have demonstrated
significantly longer progression-free survival (… The gefitinib trials are completed and none …

Erlotinib, gefitinib, or chemotherapy for EGFR mutation-positive lung cancer?

T Mitsudomi - The Lancet Oncology, 2011 - thelancet.com
… Compared with standard chemotherapy, erlotinib conferred a significant progression-free
survival benefit in patients with advanced EGFR mutation-positive NSCLC and was associated …

Comparison of gefitinib, erlotinib and afatinib in non‐small cell lung cancer: a meta‐analysis

Z Yang, A Hackshaw, Q Feng, X Fu… - … journal of cancer, 2017 - Wiley Online Library
… Korea directly compared gefitinib with erlotinib for the second… results on progression-free
survival, overall survival, overall … with direct comparison of gefitinib with erlotinib that had been …

[HTML][HTML] Gefitinib or erlotinib as maintenance therapy in patients with advanced stage non-small cell lung cancer: a systematic review

X Chen, Y Liu, OD Røe, Y Qian, R Guo, L Zhu, Y Yin… - PloS one, 2013 - journals.plos.org
… maintenance of pemetrexed significantly improved the overall survival (OS) in advanced …
of progression-free survival (PFS) and overall survival (OS) with maintenance erlotinib

[HTML][HTML] A phase III randomised controlled trial of erlotinib vs gefitinib in advanced non-small cell lung cancer with EGFR mutations

JJ Yang, Q Zhou, HH Yan, XC Zhang, HJ Chen… - British journal of …, 2017 - nature.com
… Eligible patients were randomised to receive erlotinib (150 mg per day) or gefitinib (250 …
erlotinib is superior to gefitinib in efficacy. The primary end point was progression-free survival

Comparison of gefitinib versus erlotinib in patients with nonsmall cell lung cancer who failed previous chemotherapy

ST Kim, J Lee, J Kim, YW Won, JM Sun, J Yun… - Cancer, 2010 - Wiley Online Library
… With 13.2 months of follow-up, the median overall survival (OS) for the total 342 patients …
median progression-free survival (PFS) was 3.2 months (95% CI, 2.65-3.75 months). The overall

Gefitinib and erlotinib in metastatic non-small cell lung cancer: a meta-analysis of toxicity and efficacy of randomized clinical trials

M Burotto, EE Manasanch, J Wilkerson, T Fojo - The oncologist, 2015 - academic.oup.com
… Median overall survival was 6.7 and 4.7 months for erlotinib … evidence with erlotinib and
gefitinib indicates gefitinib's activity … patients with NSCLC is at least as good as that of erlotinib. …