… While our findings thus underscore the role of GLUT1-mediated glucose metabolism in
gefitinib resistance, it may be worth noting here that, consistent with a previous observation that …

… drug transport systems, in particular inhibiting MPP, glucose … drug resistance by inhibiting
the transporter function of … we investigated whether gefitinib inhibited the transporter function of …

… In the current study, as shown in Figure 8, we show that a combination of apigenin +
gefitinib in EGFR-mutated, TKI-resistant NSCLC will induce metabolic stress and energetic …

… as models for gefitinib-sensitive and gefitinib-resistant cells. … Furthermore, gefitinib-resistant
cell lines did not show a … lines, gefitinib leads to the translocation of glucose transporters from …

… However, gefitinib treatment only decreased the glutamine … level of glucose consumption
when treated with gefitinib, but the … not glucose metabolism, correlate with gefitinib resistance in …

… of glucose transporter-1 (Glut-1) transporters from cytosolic … that PDAC resistance to axitinib
results in increased glucose … MET amplification leads to gefitinib resistance in lung cancer …

… into cellular perturbations that accompany acquired gefitinib resistance in lung cancer cells.
… , we generated gefitinib-resistant H1650 clone by long-term, chronic culture under gefitinib …

… gefitinib. We also report on the toxicity of long-term administration of PX-866, showing that it
increases blood glucose … transporter-4 to the plasma membrane (45). It has been suggested …

… gefitinib (IC 50 … to gefitinib. Collectively, these data demonstrate that E5, a dual inhibitor
of PKM2/PDK1, may be a promising adjunct to gefitinib in the treatment of EGFR-TKIs resistant …

… A effectively suppressed gefitinib-resistant tumor growth. … gefitinib-induced DTPs by exposing
PC9 cells to gefitinib (2 μM… showed upregulation of the glucose transporters Glut1 and Glut3…